EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin (Q40740746)

23 September 2017

EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin (English)

1 reference

23 September 2017

Clostridium difficile

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Clostridium perfringens

object named as

Clostridium perfringens

1 reference

inferred from title

Clostridium botulinum

1 reference

Klaus Aktories

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Cesare Montecucco

object named as

Cesare Montecucco

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Domenico Azarnia Tehran

object named as

Domenico Azarnia Tehran

0 references

Andrea Mattarei

0 references

Leonie Schnell

1 reference

23 September 2017

Ann-Katrin Mittler

1 reference

23 September 2017

Mirko Sadi

1 reference

23 September 2017

Michel R Popoff

1 reference

23 September 2017

Carsten Schwan

1 reference

23 September 2017

Holger Barth

1 reference

23 September 2017

1 April 2016

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23 September 2017

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23 September 2017

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23 September 2017

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23 September 2017

101

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Creative Commons Attribution 4.0 International

23 September 2017

start time

1 April 2016

1 reference

April 2022 Public Data File from Crossref

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4848627/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Cyclophilin-facilitated membrane translocation as pharmacological target to prevent intoxication of mammalian cells by binary clostridial actin ADP-ribosylated toxins

24 September 2017

1 reference

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Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence

24 September 2017

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Clostridium difficile binary toxin CDT: mechanism, epidemiology, and potential clinical importance

24 September 2017

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Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses

24 September 2017

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Importance of toxin A, toxin B, and CDT in virulence of an epidemic Clostridium difficile strain

24 September 2017

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Clostridium difficile binary toxin CDT induces clustering of the lipolysis-stimulated lipoprotein receptor into lipid rafts

24 September 2017

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CD44 Promotes intoxication by the clostridial iota-family toxins

24 September 2017

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Identification of the cellular receptor of Clostridium spiroforme toxin

24 September 2017

1 reference

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Clostridium perfringens iota-toxin: structure and function.

24 September 2017

1 reference

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Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT)

24 September 2017

1 reference

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Membrane translocation of binary actin-ADP-ribosylating toxins from Clostridium difficile and Clostridium perfringens is facilitated by cyclophilin A and Hsp90.

24 September 2017

1 reference

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New insights into the mode of action of the actin ADP-ribosylating virulence factors Salmonella enterica SpvB and Clostridium botulinum C2 toxin

24 September 2017

1 reference

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Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Characterization of Clostridium difficile strains isolated from patients in Ontario, Canada, from 2004 to 2006

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens -toxin

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Structure and mode of action of clostridial glucosylating toxins: the ABCD model

24 September 2017

1 reference

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Anthrax toxin: receptor binding, internalization, pore formation, and translocation

24 September 2017

1 reference

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An epidemic, toxin gene-variant strain of Clostridium difficile

24 September 2017

1 reference

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Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins

24 September 2017

1 reference

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Prevalence and characterization of a binary toxin (actin-specific ADP-ribosyltransferase) from Clostridium difficile.

24 September 2017

1 reference

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The host cell chaperone Hsp90 is necessary for cytotoxic action of the binary iota-like toxins

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

The host cell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Clostridium perfringens iota toxin: characterization of the cell-associated iota b complex

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Characterization of the enzymatic component of the ADP-ribosyltransferase toxin CDTa from Clostridium difficile

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Cellular uptake of the Clostridium perfringens binary iota-toxin

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Clostridium perfringens iota toxin: binding studies and characterization of cell surface receptor by fluorescence-activated cytometry

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Production of actin-specific ADP-ribosyltransferase (binary toxin) by strains of Clostridium difficile

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Cellular uptake of Clostridium botulinum C2 toxin requires oligomerization and acidification

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Binding of Clostridium botulinum C2 toxin to asparagine-linked complex and hybrid carbohydrates

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Production of a complete binary toxin (actin-specific ADP-ribosyltransferase) by Clostridium difficile CD196.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Clostridial enteric diseases of domestic animals

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Glucosylation of Rho proteins by Clostridium difficile toxin B.

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Botulinum C2 toxin ADP-ribosylates cytoplasmic beta/gamma-actin in arginine 177

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Actin-specific ADP-ribosyltransferase produced by a Clostridium difficile strain

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Purification and characterization of Clostridium perfringens iota toxin: dependence on two nonlinked proteins for biological activity

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

ADP-ribosylation of actin by clostridial toxins

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Purification and characterization of two components of botulinum C2 toxin

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

The long-lived nature of clostridium perfringens iota toxin in mammalian cells induces delayed apoptosis

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

ADP-ribosylation of actin by the Clostridium botulinum C2 toxin in mammalian cells results in delayed caspase-dependent apoptotic cell death.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Channel formation by the binding component of Clostridium botulinum C2 toxin: glutamate 307 of C2II affects channel properties in vitro and pH-dependent C2I translocation in vivo

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Interaction of Clostridium perfringens iota-toxin with lipid bilayer membranes. Demonstration of channel formation by the activated binding component Ib and channel block by the enzyme component Ia.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Evidence that Arg-295, Glu-378, and Glu-380 are active-site residues of the ADP-ribosyltransferase activity of iota toxin

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Interaction of Clostridium botulinum C2 toxin with lipid bilayer membranes. Formation of cation-selective channels and inhibition of channel function by chloroquine

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

ADP-ribosylation of nonmuscle actin with component I of C2 toxin

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Clostridium perfringens iota toxin ADP-ribosylates skeletal muscle actin in Arg-177.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Clostridium perfringens iota toxin: synergism between two proteins

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Alteration of the cytoskeleton of mammalian cells cultured in vitro by Clostridium botulinum C2 toxin and C3 ADP-ribosyltransferase.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Cyclophilin A facilitates translocation of the Clostridium botulinum C2 toxin across membranes of acidified endosomes into the cytosol of mammalian cells

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Amino acid residues involved in membrane insertion and pore formation of Clostridium botulinum C2 toxin

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Distribution of Clostridium difficile variant toxinotypes and strains with binary toxin genes among clinical isolates in an American hospital

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Cellular uptake of Clostridium botulinum C2 toxin: membrane translocation of a fusion toxin requires unfolding of its dihydrofolate reductase domain

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Clostridium botulinum C2 toxin: low pH-induced pore formation is required for translocation of the enzyme component C2I into the cytosol of host cells

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Interaction of Clostridium botulinum C2 toxin with lipid bilayer membranes and Vero cells: inhibition of channel function by chloroquine and related compounds in vitro and intoxification in vivo.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4848627

Differential requirement for the translocation of clostridial binary toxins: Iota toxin requires a membrane potential gradient

19 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.3390%2FTOXINS8040101

Botulinum C2 toxin ADP-ribosylates actin

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.3390%2FTOXINS8040101

Clostridium difficile infection

21 January 2018

1 reference

12 December 2020

FK506-binding protein 51 interacts with Clostridium botulinum C2 toxin and FK506 inhibits membrane translocation of the toxin in mammalian cells

1 reference

12 December 2020

ADP-ribosylation of skeletal muscle and non-muscle actin by Clostridium perfringens iota toxin

1 reference

12 December 2020

ADP-ribosylated actin caps the barbed ends of actin filaments

1 reference

12 December 2020

Nonmuscle actin ADP-ribosylated by botulinum C2 toxin caps actin filaments

1 reference

12 December 2020

Characterization of the catalytic site of the ADP-ribosyltransferase Clostridium botulinum C2 toxin by site-directed mutagenesis

1 reference

12 December 2020

Structure and action of the binary C2 toxin from Clostridium botulinum

1 reference

12 December 2020

Identifiers

DOI

10.3390/TOXINS8040101

1 reference

23 September 2017

1 reference

23 September 2017

PubMed publication ID

27043629

1 reference