The carboxyl-terminal region of human cytomegalovirus IE1491aa contains an acidic domain that plays a regulatory role and a chromatin-tethering domain that is dispensable during viral replication (Q40727824)

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English	The carboxyl-terminal region of human cytomegalovirus IE1491aa contains an acidic domain that plays a regulatory role and a chromatin-tethering domain that is dispensable during viral replication	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

23 September 2017

The carboxyl-terminal region of human cytomegalovirus IE1491aa contains an acidic domain that plays a regulatory role and a chromatin-tethering domain that is dispensable during viral replication (English)

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Europe PubMed Central

PMC publication ID

23 September 2017

Cytomegalovirus

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author name string

Jens Reinhardt

1

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Europe PubMed Central

PMC publication ID

23 September 2017

Geoffrey B Smith

2

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Europe PubMed Central

PMC publication ID

23 September 2017

Christopher T Himmelheber

3

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Europe PubMed Central

PMC publication ID

23 September 2017

Jane Azizkhan-Clifford

4

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Europe PubMed Central

PMC publication ID

23 September 2017

Edward S Mocarski

5

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Europe PubMed Central

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23 September 2017

language of work or name

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publication date

1 January 2005

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Europe PubMed Central

PMC publication ID

23 September 2017

Journal of Virology

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Europe PubMed Central

PMC publication ID

23 September 2017

79

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Europe PubMed Central

PMC publication ID

23 September 2017

1

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

225-233

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

Global analysis of host cell gene expression late during cytomegalovirus infection reveals extensive dysregulation of cell cycle gene expression and induction of Pseudomitosis independent of US28 function

1 reference

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Small internal deletions in the human cytomegalovirus IE2 gene result in nonviable recombinant viruses with differential defects in viral gene expression.

1 reference

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HCMV infection: modulating the cell cycle and cell death

1 reference

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Interactions between Human Cytomegalovirus IE1-72 and Cellular p107: Functional Domains and Mechanisms of Up-Regulation of Cyclin E/cdk2 Kinase Activity

1 reference

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25 September 2017

Metaphase chromosome tethering is necessary for the DNA synthesis and maintenance of oriP plasmids but is insufficient for transcription activation by Epstein-Barr nuclear antigen 1.

1 reference

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25 September 2017

Human cytomegalovirus immediate early proteins and cell growth control

1 reference

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25 September 2017

Infection of cells with human cytomegalovirus during S phase results in a blockade to immediate-early gene expression that can be overcome by inhibition of the proteasome

1 reference

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Absence of IE1 p72 protein function during low-multiplicity infection by human cytomegalovirus results in a broad block to viral delayed-early gene expression

1 reference

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Novel immediate-early protein IE19 of human cytomegalovirus activates the origin recognition complex I promoter in a cooperative manner with IE72.

1 reference

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25 September 2017

SUMO-1 modification of human cytomegalovirus IE1/IE72

1 reference

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Altered cellular mRNA levels in human cytomegalovirus-infected fibroblasts: viral block to the accumulation of antiviral mRNAs

1 reference

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Proteasome-independent disruption of PML oncogenic domains (PODs), but not covalent modification by SUMO-1, is required for human cytomegalovirus immediate-early protein IE1 to inhibit PML-mediated transcriptional repression.

1 reference

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Close but distinct regions of human herpesvirus 8 latency-associated nuclear antigen 1 are responsible for nuclear targeting and binding to human mitotic chromosomes

1 reference

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Human cytomegalovirus with IE-2 (UL122) deleted fails to express early lytic genes

1 reference

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The immediate early gene 1 product of human cytomegalovirus is sufficient for up-regulation of interleukin-8 gene expression.

1 reference

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The major immediate-early gene ie3 of mouse cytomegalovirus is essential for viral growth

1 reference

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Disruption of PML-associated nuclear bodies by IE1 correlates with efficient early stages of viral gene expression and DNA replication in human cytomegalovirus infection

1 reference

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25 September 2017

Mechanisms of viral activators

1 reference

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Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruption

1 reference

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25 September 2017

Human cytomegalovirus IE1 protein activates AP-1 through a cellular protein kinase(s)

1 reference

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Mapping EBNA-1 domains involved in binding to metaphase chromosomes.

1 reference

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25 September 2017

Cytomegalovirus remains latent in a common precursor of dendritic and myeloid cells

1 reference

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Defective Growth Correlates with Reduced Accumulation of a Viral DNA Replication Protein after Low-Multiplicity Infection by a Human Cytomegalovirus ie1 Mutant

1 reference

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Identification of a Viral Kinase That Phosphorylates Specific E2Fs and Pocket Proteins

1 reference

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The major immediate-early proteins IE1 and IE2 of human cytomegalovirus colocalize with and disrupt PML-associated nuclear bodies at very early times in infected permissive cells.

1 reference

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Human cytomagalovirus IE1 and IE2 proteins are mutagenic and mediate "hit-and-run" oncogenic transformation in cooperation with the adenovirus E1A proteins

1 reference

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The nuclear domain 10 (ND10) is disrupted by the human cytomegalovirus gene product IE1

1 reference

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A deletion mutant in the human cytomegalovirus gene encoding IE1(491aa) is replication defective due to a failure in autoregulation

1 reference

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Human cytomegalovirus latent gene expression in granulocyte-macrophage progenitors in culture and in seropositive individuals

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Human cytomegalovirus late protein encoded by ie2: a trans-activator as well as a repressor of gene expression

1 reference

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CCAAT box-dependent activation of the TATA-less human DNA polymerase alpha promoter by the human cytomegalovirus 72-kilodalton major immediate-early protein

1 reference

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Human cytomegalovirus IE1 and IE2 proteins block apoptosis

1 reference

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Interaction of the 72-kilodalton human cytomegalovirus IE1 gene product with E2F1 coincides with E2F-dependent activation of dihydrofolate reductase transcription

1 reference

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Mutants of GAL4 protein altered in an activation function

1 reference

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NF-kappa B activation of the cytomegalovirus enhancer is mediated by a viral transactivator and by T cell stimulation

1 reference

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Human cytomegalovirus ie1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element.

1 reference

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The functionally active IE2 immediate-early regulatory protein of human cytomegalovirus is an 80-kilodalton polypeptide that contains two distinct activator domains and a duplicated nuclear localization signal

1 reference

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The functional importance of a cap site-proximal region of the human prointerleukin 1 beta gene is defined by viral protein trans-activation

1 reference

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Disruption of PML-associated nuclear bodies mediated by the human cytomegalovirus major immediate early gene product

1 reference

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Recombinant cytomegaloviruses for study of replication and pathogenesis

1 reference

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Regulation of expression of the IL-1 receptor antagonist (IL-1ra) gene by products of the human cytomegalovirus immediate early genes

1 reference

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Differences in cell-type-specific blocks to immediate early gene expression and DNA replication of human, simian and murine cytomegalovirus

1 reference

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Expression of the acidic nuclear immediate-early protein (IE1) of human cytomegalovirus in stable cell lines and its preferential association with metaphase chromosomes

1 reference

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Primary chimpanzee skin fibroblast cells are fully permissive for human cytomegalovirus replication

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The 72K IE1 and 80K IE2 proteins of human cytomegalovirus independently trans-activate the c-fos, c-myc and hsp70 promoters via basal promoter elements

1 reference

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Repression of human cytomegalovirus major immediate early gene expression in a monocytic cell line

1 reference

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Engineered RNase P ribozymes are efficient in cleaving a human cytomegalovirus mRNA in vitro and are effective in inhibiting viral gene expression and growth in human cells

1 reference

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Structural Organization of the Spliced Immediate-Early Gene Complex that Encodes the Major Acidic Nuclear (IE1) and Transactivator (IE2) Proteins of African Green Monkey Cytomegalovirus

1 reference

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Critical structural elements of the VP16 transcriptional activation domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15596818

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytomegalovirus modulates interleukin-6 gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/15596818

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subcellular localization of the major immediate early protein (IE1) of human cytomegalovirus at early times after infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/15596818

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Domain mapping of the human cytomegalovirus IE1-72 and cellular p107 protein-protein interaction and the possible functional consequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/15596818

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.79.1.225-233.2005

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

ResearchGate publication ID

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