Engineered RNase P ribozymes are efficient in cleaving a human cytomegalovirus mRNA in vitro and are effective in inhibiting viral gene expression and growth in human cells (Q45863741)

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scientific article published on 15 July 2003

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English	Engineered RNase P ribozymes are efficient in cleaving a human cytomegalovirus mRNA in vitro and are effective in inhibiting viral gene expression and growth in human cells	scientific article published on 15 July 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/12867424

Engineered RNase P ribozymes are efficient in cleaving a human cytomegalovirus mRNA in vitro and are effective in inhibiting viral gene expression and growth in human cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/12867424

Cytomegalovirus

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2

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/12867424

author name string

Hua Zou

1

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/12867424

Sean Umamoto

3

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/12867424

Ahmed F Kilani

4

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/12867424

Joseph Kim

5

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/12867424

Phong Trang

6

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/12867424

Tianhong Zhou

7

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/12867424

Fenyong Liu

8

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/12867424

language of work or name

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publication date

15 July 2003

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/12867424

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/12867424

278

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/12867424

39

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/12867424

37265-37274

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/12867424

Ribozymes, genomics and therapeutics

1 reference

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A controlled, Phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303531200

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A hairpin ribozyme inhibits expression of diverse strains of human immunodeficiency virus type 1

1 reference

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Ribozymes as potential anti-HIV-1 therapeutic agents.

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Ribozyme-mediated repair of sickle beta-globin mRNAs in erythrocyte precursors

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Ribonuclease P: unity and diversity in a tRNA processing ribozyme

1 reference

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The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

1 reference

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Further perspective on the catalytic core and secondary structure of ribonuclease P RNA

1 reference

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Evolutionary variation in bacterial RNase P RNAs

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Molecular modeling of the three-dimensional structure of the bacterial RNase P holoenzyme

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Crystal structure of the specificity domain of ribonuclease P

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303531200

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Derivation of the three-dimensional architecture of bacterial ribonuclease P RNAs from comparative sequence analysis

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Comparative photocross-linking analysis of the tertiary structures of Escherichia coli and Bacillus subtilis RNase P RNAs.

1 reference

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External Guide Sequences for an RNA Enzyme

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303531200

21 January 2018

Model substrates for an RNA enzyme

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303531200

21 January 2018

Inhibition of viral gene expression by the catalytic RNA subunit of RNase P from Escherichia coli.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303531200

21 January 2018

Rational design of self-cleaving pre-tRNA-ribonuclease P RNA conjugates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303531200

21 January 2018

Effective inhibition of human cytomegalovirus gene expression and replication by a ribozyme derived from the catalytic RNA subunit of RNase P from Escherichia coli

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303531200

21 January 2018

Differential effects of the protein cofactor on the interactions between an RNase P ribozyme and its target mRNA substrate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303531200

21 January 2018

UV cross-link mapping of the substrate-binding site of an RNase P ribozyme to a target mRNA sequence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303531200

21 January 2018

RNase P ribozymes selected in vitro to cleave a viral mRNA effectively inhibit its expression in cell culture

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303531200

21 January 2018

Nuclease footprint analyses of the interactions between RNase P ribozyme and a model mRNA substrate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303531200

21 January 2018

Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: Induction of interferon-responsive RNAs

1 reference

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21 January 2018

Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena

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21 January 2018

Human cytomegalovirus with IE-2 (UL122) deleted fails to express early lytic genes

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21 January 2018

Lethal and temperature-sensitive mutations and their suppressors identify an essential structural element in U2 small nuclear RNA.

1 reference

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21 January 2018

Inhibition of viral gene expression by human ribonuclease P.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303531200

21 January 2018

Targeted cleavage of mRNA by human RNase P

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303531200

21 January 2018

In vitro genetics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303531200

21 January 2018

In vitro selection of active hairpin ribozymes by sequential RNA-catalyzed cleavage and ligation reactions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303531200

21 January 2018

AUA-cleaving hammerhead ribozymes: attempted selection for improved cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303531200

21 January 2018

Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303531200

21 January 2018

In vitro genetic analysis of the Tetrahymena self-splicing intron

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303531200

21 January 2018

Kinetics of intermolecular cleavage by hammerhead ribozymes

1 reference

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21 January 2018

Multiple magnesium ions in the ribonuclease P reaction mechanism

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M303531200

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/12867424

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/12867424

ResearchGate publication ID

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