Activation-induced cytidine deaminase fails to induce a mutator phenotype in the human pre-B cell line Nalm-6. (Q40481554)

20 September 2017

title

Activation-induced cytidine deaminase fails to induce a mutator phenotype in the human pre-B cell line Nalm-6. (English)

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20 September 2017

Florian Rückerl

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20 September 2017

Jurgen Bachl

series ordinal

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20 September 2017

language of work or name

English

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publication date

1 January 2005

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European Journal of Immunology

20 September 2017

published in

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20 September 2017

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20 September 2017

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20 September 2017

page(s)

290-298

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Clonal selection and learning in the antibody system

20 September 2017

cites work

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Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

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Within germinal centers, isotype switching of immunoglobulin genes occurs after the onset of somatic mutation

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Intraclonal generation of antibody mutants in germinal centres

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Maturation of the immune response in germinal centers

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Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation

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AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

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AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

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Somatic hypermutation of the AID transgene in B and non-B cells

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Constitutive expression of AID leads to tumorigenesis

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Alternative mRNA splicing and differential promoter utilization determine tissue-specific expression of the apolipoprotein B mRNA-editing protein (Apobec1) gene in mice. Structure and evolution of Apobec1 and related nucleoside/nucleotide deaminases

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Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

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Transcription-targeted DNA deamination by the AID antibody diversification enzyme

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AID mediates hypermutation by deaminating single stranded DNA.

21 January 2018

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Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

21 January 2018

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Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation

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An immunoglobulin mutator that targets G.C base pairs

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Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

21 January 2018

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DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

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Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

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Genome-wide somatic hypermutation

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Somatic hypermutation in the heavy chain locus correlates with transcription

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AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization

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Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

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Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks

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Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

21 January 2018

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Intracellular trafficking determinants in APOBEC-1, the catalytic subunit for cytidine to uridine editing of apolipoprotein B mRNA

21 January 2018

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A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling

21 January 2018

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AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line

21 January 2018

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Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin

21 January 2018

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7 January 2021

Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

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7 January 2021

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

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7 January 2021

Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene

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7 January 2021

Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

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7 January 2021

pEF-BOS, a powerful mammalian expression vector

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7 January 2021

Characterization of a leukemic cell line of the pre-B phenotype

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7 January 2021

Mutational pattern of the nurse shark antigen receptor gene (NAR) is similar to that of mammalian Ig genes and to spontaneous mutations in evolution: the translesion synthesis model of somatic hypermutation

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https://api.crossref.org/works/10.1002%2FEJI.200425315

7 January 2021

Increased transcription levels induce higher mutation rates in a hypermutating cell line

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https://api.crossref.org/works/10.1002%2FEJI.200425315

7 January 2021

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200425315

7 January 2021

Identifiers

DOI

10.1002/EJI.200425315

1 reference

20 September 2017

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