A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3'-kinase activation and endothelial cell migration (Q40392328)

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English	A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3'-kinase activation and endothelial cell migration	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

20 September 2017

A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3'-kinase activation and endothelial cell migration (English)

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

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author name string

H Gille

1

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

J Kowalski

2

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Europe PubMed Central

PMC publication ID

20 September 2017

L Yu

3

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

H Chen

4

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

M T Pisabarro

5

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

T Davis-Smyth

6

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Europe PubMed Central

PMC publication ID

20 September 2017

N Ferrara

7

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Europe PubMed Central

PMC publication ID

20 September 2017

language of work or name

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publication date

1 August 2000

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Europe PubMed Central

PMC publication ID

20 September 2017

The EMBO Journal

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Europe PubMed Central

PMC publication ID

20 September 2017

19

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

15

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

4064-4073

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors

1 reference

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Role of vascular endothelial growth factor in the regulation of angiogenesis

1 reference

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Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis

1 reference

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22 September 2017

Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization

1 reference

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22 September 2017

Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1

1 reference

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A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases

1 reference

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A single amino acid substitution in a WW-like domain of diverse members of the PDGF receptor subfamily of tyrosine kinases causes constitutive receptor activation

1 reference

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Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

1 reference

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Sck interacts with KDR and Flt-1 via its SH2 domain

1 reference

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Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules

1 reference

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Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice

1 reference

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Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2.

1 reference

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Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor

1 reference

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Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-gamma and migration of endothelial cells expressing Flt 1

1 reference

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The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma

1 reference

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Signalling through the lipid products of phosphoinositide-3-OH kinase

1 reference

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Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

1 reference

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Structure of the WW domain of a kinase-associated protein complexed with a proline-rich peptide.

1 reference

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Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1

1 reference

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Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor

1 reference

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Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR

1 reference

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A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF

1 reference

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Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases

1 reference

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Interaction of the Flt-1 tyrosine kinase receptor with the p85 subunit of phosphatidylinositol 3-kinase. Mapping of a novel site involved in binding

1 reference

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Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1 reference

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Rapid and efficient site-specific mutagenesis without phenotypic selection

1 reference

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Purification and properties of an endothelial cell growth factor from human platelets

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Vascular endothelial growth factor is a secreted angiogenic mitogen

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Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family

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Activation of phosphatidylinositol 3-kinase by insulin

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Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor

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1 reference

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1 reference

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Loss of the exon encoding the juxtamembrane domain is essential for the oncogenic activation of TPR-MET.

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306589

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1 reference

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306589

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=306589

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1 reference

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1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2F19.15.4064

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

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inferred from PubMed ID database lookup

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1 reference

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inferred from PubMed ID database lookup

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1 reference

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inferred from PubMed ID database lookup

Identifiers

10.1093/EMBOJ/19.15.4064

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

ResearchGate publication ID

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