Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice (Q28504776)

24 January 2017

title

Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice (English)

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FMS-like tyrosine kinase 1

24 January 2017

main subject

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GOA release 2020-03-11

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S. Hiratsuka

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24 January 2017

O. Minowa

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24 January 2017

J. Kuno

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24 January 2017

T. Noda

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24 January 2017

M. Shibuya

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24 January 2017

language of work or name

English

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publication date

4 August 1998

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Proceedings of the National Academy of Sciences of the United States of America

24 January 2017

published in

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24 January 2017

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24 January 2017

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24 January 2017

page(s)

9349–9354

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The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma

24 January 2017

cites work

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The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts

19 March 2017

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Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development

19 March 2017

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Nuk controls pathfinding of commissural axons in the mammalian central nervous system

19 March 2017

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The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo

19 March 2017

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Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1

19 March 2017

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Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium

19 March 2017

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Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor

19 March 2017

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Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements

19 March 2017

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A new communication system between hepatocytes and sinusoidal endothelial cells in liver through vascular endothelial growth factor and Flt tyrosine kinase receptor family (Flt-1 and KDR/Flk-1)

19 March 2017

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Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor

19 March 2017

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Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR

19 March 2017

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A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF

19 March 2017

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Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

19 March 2017

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Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

19 March 2017

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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

19 March 2017

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Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family

19 March 2017

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Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor

19 March 2017

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Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

19 March 2017

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Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

19 March 2017

1 reference

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Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

19 March 2017

1 reference

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Mechanisms of angiogenesis

19 March 2017

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Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

7 April 2017

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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

7 April 2017

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The biology of vascular endothelial growth factor

7 April 2017

1 reference

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Growth factor signaling by receptor tyrosine kinases

7 April 2017

1 reference

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Genomic organization of the flt-1 gene encoding for vascular endothelial growth factor (VEGF) receptor-1 suggests an intimate evolutionary relationship between the 7-Ig and the 5-Ig tyrosine kinase receptors

7 April 2017

1 reference

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Characterization of the extracellular domain in vascular endothelial growth factor receptor-1 (Flt-1 tyrosine kinase).

29 September 2017

1 reference

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Mapping of the sites for ligand binding and receptor dimerization at the extracellular domain of the vascular endothelial growth factor receptor FLT-1.

29 September 2017

1 reference

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Role of VEGF-flt receptor system in normal and tumor angiogenesis.

29 September 2017

1 reference

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Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor.

29 September 2017

1 reference

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Endothelial receptor tyrosine kinases involved in angiogenesis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21341

Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21341

A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21341

Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21341

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21341

Molecular cloning of murine FLT and FLT4.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21341

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21341

Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21341

Flt-1 but not KDR/Flk-1 tyrosine kinase is a receptor for placenta growth factor, which is related to vascular endothelial growth factor.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21341

Enhanced vascular permeability and haemorrhage-inducing activity of rabbit C5ades arg: probable role of polymorphonuclear leucocyte lysosomes

27 November 2018

1 reference

12 December 2020

Two molecules related to the VEGF receptor are expressed in early endothelial cells during avian embryonic development

1 reference

12 December 2020

Specificity of vascular endothelial cell growth factor receptor ligand binding domains

1 reference

12 December 2020

The Vascular Endothelial Growth Factor Receptor Flt-1 Mediates Biological Activities

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.95.16.9349

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ADS bibcode

1998PNAS...95.9349H

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