Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake (Q40331276)

19 September 2017

title

Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake (English)

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19 September 2017

Liqing Yu

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19 September 2017

Shantaram Bharadwaj

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19 September 2017

J Mark Brown

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19 September 2017

Yinyan Ma

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19 September 2017

Wei Du

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19 September 2017

Matthew A Davis

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19 September 2017

Peter Michaely

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19 September 2017

Pingsheng Liu

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19 September 2017

Mark C Willingham

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19 September 2017

Lawrence L Rudel

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19 September 2017

language of work or name

English

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publication date

30 December 2005

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Journal of Biological Chemistry

19 September 2017

published in

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19 September 2017

volume

281

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19 September 2017

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19 September 2017

page(s)

6616-6624

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Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption

19 September 2017

cites work

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Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis

21 January 2018

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Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia.

21 January 2018

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Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function

21 January 2018

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Inhibition of intestinal cholesterol absorption by ezetimibe in humans

21 January 2018

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RETRACTED: Annexin 2-caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport

21 January 2018

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Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane

21 January 2018

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Caveolin-1 is not required for murine intestinal cholesterol transport.

21 January 2018

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The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

21 January 2018

1 reference

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Evidence for a Niemann-pick C (NPC) gene family: identification and characterization of NPC1L1.

21 January 2018

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Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

21 January 2018

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Murine Model of Niemann-Pick C Disease: Mutation in a Cholesterol Homeostasis Gene

21 January 2018

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The sterol-sensing domain: multiple families, a unique role?

21 January 2018

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Regulation of the mevalonate pathway

21 January 2018

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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

21 January 2018

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SREBPs: transcriptional mediators of lipid homeostasis

21 January 2018

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The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits

21 January 2018

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Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK).

21 January 2018

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

21 January 2018

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Cessation of rapid late endosomal tubulovesicular trafficking in Niemann-Pick type C1 disease

21 January 2018

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Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events

21 January 2018

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Characterization of the putative native and recombinant rat sterol transporter Niemann-Pick C1 Like 1 (NPC1L1) protein

21 January 2018

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21 January 2018

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Vesicular and non-vesicular sterol transport in living cells. The endocytic recycling compartment is a major sterol storage organelle

21 January 2018

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Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog

21 January 2018

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Rapid nonvesicular transport of sterol between the plasma membrane domains of polarized hepatic cells

21 January 2018

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Segregation of transferrin to a mildly acidic (pH 6.5) para-Golgi compartment in the recycling pathway

21 January 2018

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Acute cholesterol depletion inhibits clathrin-coated pit budding

21 January 2018

1 reference

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Evidence for apical endocytosis in polarized hepatic cells: phosphoinositide 3-kinase inhibitors lead to the lysosomal accumulation of resident apical plasma membrane proteins

21 January 2018

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WIF-B cells: an in vitro model for studies of hepatocyte polarity

21 January 2018

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Isolated rat hepatocyte couplets: a primary secretory unit for electrophysiologic studies of bile secretory function

21 January 2018

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Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain

21 January 2018

1 reference

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Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M511123200

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19 September 2017

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