Evidence for apical endocytosis in polarized hepatic cells: phosphoinositide 3-kinase inhibitors lead to the lysosomal accumulation of resident apical plasma membrane proteins (Q36256502)

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English	Evidence for apical endocytosis in polarized hepatic cells: phosphoinositide 3-kinase inhibitors lead to the lysosomal accumulation of resident apical plasma membrane proteins	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Evidence for apical endocytosis in polarized hepatic cells: phosphoinositide 3-kinase inhibitors lead to the lysosomal accumulation of resident apical plasma membrane proteins (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

membrane protein

1 reference

based on heuristic

inferred from title

author name string

P L Tuma

1

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

C M Finnegan

2

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

J H Yi

3

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

A L Hubbard

4

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

language of work or name

0 references

publication date

1 May 1999

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Europe PubMed Central

PMC publication ID

13 August 2017

number of pages

14

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based on heuristic

inferred from page(s)

Journal of Cell Biology

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Europe PubMed Central

PMC publication ID

13 August 2017

145

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

5

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

1089-1102

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Multivesicular body morphogenesis requires phosphatidyl-inositol 3-kinase activity

1 reference

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Distinct roles for the p110alpha and hVPS34 phosphatidylinositol 3'-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis

1 reference

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Receptor-mediated endocytosis of albumin by kidney proximal tubule cells is regulated by phosphatidylinositide 3-kinase

1 reference

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Apical plasma membrane proteins and endolyn-78 travel through a subapical compartment in polarized WIF-B hepatocytes.

1 reference

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Hepatic secretion of phospholipid vesicles in the mouse critically depends on mdr2 or MDR3 P-glycoprotein expression. Visualization by electron microscopy

1 reference

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Phosphoinositide 3-kinases: A conserved family of signal transducers

1 reference

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Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase.

1 reference

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Signalling through the lipid products of phosphoinositide-3-OH kinase

1 reference

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Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains

1 reference

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Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro

1 reference

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Apical and basolateral endosomes of MDCK cells are interconnected and contain a polarized sorting mechanism

1 reference

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30 September 2017

Phosphoinositide kinases

1 reference

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Role of vesicle-mediated transport pathways in hepatocellular bile secretion

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Potential sites of PI-3 kinase function in the endocytic pathway revealed by the PI-3 kinase inhibitor, wortmannin

1 reference

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Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes

1 reference

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30 September 2017

Phosphoinositides as regulators in membrane traffic

1 reference

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Receptor-mediated transcytosis of IgA in MDCK cells is via apical recycling endosomes

1 reference

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A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

1 reference

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Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1 reference

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Inhibition of apical but not basolateral endocytosis of ricin and folate in Caco-2 cells by cytochalasin D.

1 reference

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Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase.

1 reference

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Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells

1 reference

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Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport

1 reference

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Membrane protein trafficking through the common apical endosome compartment of polarized Caco-2 cells.

1 reference

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WIF-B cells: an in vitro model for studies of hepatocyte polarity

1 reference

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Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5.

1 reference

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Identification of rat hepatocyte plasma membrane proteins using monoclonal antibodies.

1 reference

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Biogenesis of the rat hepatocyte plasma membrane in vivo: comparison of the pathways taken by apical and basolateral proteins using subcellular fractionation

1 reference

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Endocytosis in filter-grown Madin-Darby canine kidney cells.

1 reference

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Meeting of the apical and basolateral endocytic pathways of the Madin-Darby canine kidney cell in late endosomes.

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5'nucleotidase is sorted to the apical domain of hepatocytes via an indirect route

1 reference

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Rat liver dipeptidylpeptidase IV contains competing apical and basolateral targeting information

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Wortmannin inhibits transcytosis of dimeric IgA by the polymeric immunoglobulin receptor

1 reference

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Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking

1 reference

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Phosphatidylinositol 3-kinase activity is required for early endosome fusion.

1 reference

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Wortmannin, an inhibitor of phosphoinositide 3-kinase, inhibits transcytosis in polarized epithelial cells

1 reference

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1 reference

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1 reference

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Regulation of endocytic-transcytotic pathways and bile secretion by phosphatidylinositol 3-kinase in rats.

1 reference

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Actin microfilaments play a critical role in endocytosis at the apical but not the basolateral surface of polarized epithelial cells

1 reference

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Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites.

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Basolateral to apical transcytosis in polarized cells is indirect and involves BFA and trimeric G protein sensitive passage through the apical endosome

1 reference

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Wortmannin causes mistargeting of procathepsin D. evidence for the involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomes

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29 June 2018

Endocytic pathways in polarized Caco-2 cells: identification of an endosomal compartment accessible from both apical and basolateral surfaces

1 reference

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1 reference

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29 June 2018

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The effects of cytochalasin D and phorbol myristate acetate on the apical endocytosis of ricin in polarised Caco-2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10352024

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1 reference

https://pubmed.ncbi.nlm.nih.gov/10352024

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1 reference

https://pubmed.ncbi.nlm.nih.gov/10352024

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based on heuristic

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Biochemical characterization of domain-specific glycoproteins of the rat hepatocyte plasma membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/10352024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of calmodulin antagonists on endocytosis and intracellular transport of ricin in polarized MDCK cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10352024

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inferred from PubMed ID database lookup

Plasma membrane protein sorting in epithelial cells: do secretory pathways hold the key?

1 reference

https://pubmed.ncbi.nlm.nih.gov/10352024

12 December 2020

based on heuristic

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Immunoadsorption of hepatic vesicles carrying newly synthesized dipeptidyl peptidase IV and polymeric IgA receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10352024

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Newly synthesized hepatocyte plasma membrane proteins are transported in transcytotic vesicles in the bile duct-ligated rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/10352024

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based on heuristic

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The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10352024

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based on heuristic

inferred from PubMed ID database lookup

Multivesicular bodies in HEp-2 cells are maturing endosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10352024

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based on heuristic

inferred from PubMed ID database lookup

18 Use of isolated, perfused liver in studies of receptor-mediated endocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10352024

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based on heuristic

inferred from PubMed ID database lookup

Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/10352024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of wortmannin on the localisation of lysosomal type I integral membrane glycoproteins suggests a role for phosphoinositide 3-kinase activity in regulating membrane traffic late in the endocytic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/10352024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1083/JCB.145.5.1089

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

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