Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. (Q44251931)

PubMed publication ID

12486162

1 December 2017

title

Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease (English)

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12 May 2020

main subject

endoplasmic reticulum

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oxidopamine

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ChEBI release 2020-05-28

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758450&resulttype=core&format=json

12 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758450&resulttype=core&format=json

12 May 2020

Elizabeth J Ryu

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12 May 2020

James M Angelastro

series ordinal

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12 May 2020

Ottavio V Vitolo

series ordinal

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12 May 2020

Lloyd A Greene

series ordinal

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12 May 2020

language of work or name

English

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publication date

1 December 2002

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PubMed publication ID

12486162

1 December 2017

published in

Journal of Neuroscience

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12 May 2020

volume

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12 May 2020

issue

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12 May 2020

page(s)

10690-10698

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Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response

12 May 2020

cites work

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12 December 2020

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

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12 December 2020

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

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12 December 2020

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

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12 December 2020

Caspase-2 mediates neuronal cell death induced by beta-amyloid

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12 December 2020

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

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12 December 2020

Tripartite management of unfolded proteins in the endoplasmic reticulum

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12 December 2020

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

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12 December 2020

Neuroprotective strategies in Parkinson's disease using the models of 6-hydroxydopamine and MPTP.

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12 December 2020

A regulatory link between ER-associated protein degradation and the unfolded-protein response

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12 December 2020

Perk is essential for translational regulation and cell survival during the unfolded protein response

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12 December 2020

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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12 December 2020

Identification of diverse nerve growth factor-regulated genes by serial analysis of gene expression (SAGE) profiling.

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12 December 2020

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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12 December 2020

Regulated translation initiation controls stress-induced gene expression in mammalian cells

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12 December 2020

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

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12 December 2020

Caspase 3 inhibition attenuates hydrogen peroxide-induced DNA fragmentation but not cell death in neuronal PC12 cells.

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12 December 2020

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

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12 December 2020

Impairment of the ubiquitin-proteasome system by protein aggregation

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12 December 2020

Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death

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12 December 2020

Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms

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12 December 2020

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

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12 December 2020

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

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12 December 2020

Failure of the ubiquitin-proteasome system in Parkinson's disease

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12 December 2020

Organelle-specific initiation of cell death pathways

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12 December 2020

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

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12 December 2020

Recent advances in the genetics and pathogenesis of Parkinson disease

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12 December 2020

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

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12 December 2020

Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease

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12 December 2020

Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

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12 December 2020

Intermediates in the aerobic autoxidation of 6-hydroxydopamine: relative importance under different reaction conditions

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12 December 2020

cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor

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12 December 2020

Phosphorylation of eukaryotic initiation factor 2 during physiological stresses which affect protein synthesis

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12 December 2020

Behavioral, physiological, and neurochemical changes after 6-hydroxydopamine-induced degeneration of the nigro-striatal dopamine neurons

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12 December 2020

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

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12 December 2020

Characterization of antisera raised against cultured rat sympathetic neurons

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12 December 2020

Neurotoxin-induced cell death in neuronal PC12 cells is mediated by induction of apoptosis

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12 December 2020

Serial analysis of gene expression

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12 December 2020

1-Methyl-4-phenylpyridinium (MPP+)-induced cell death in PC12 cells: inhibitory effects of several drugs

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12 December 2020

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12 December 2020

Transfection with trk restores "slow" NGF binding, efficient NGF uptake, and multiple NGF responses to NGF-nonresponsive PC12 cell mutants

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12 December 2020

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease

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12 December 2020

Induction of the mammalian stress response gene GADD153 by oxidative stress: role of AP-1 element

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12 December 2020

Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).

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12 December 2020

6-Hydroxydopamine-mediated induction of rat brain metallothionein I mRNA

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12 December 2020

bcl-2 protein is increased in the brain from parkinsonian patients

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12 December 2020

G1/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis

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12 December 2020

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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12 December 2020

Mitochondrial toxins in models of neurodegenerative diseases. II: elevated zif268 transcription and independent temporal regulation of striatal D1 and D2 receptor mRNAs and D1 and D2 receptor-binding sites in C57BL/6 mice during MPTP treatment

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12 December 2020

Neuropathology of Autonomic Nervous System in Parkinson's Disease

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12 December 2020

Effect of Brain Ischemia and Reperfusion on the Localization of Phosphorylated Eukaryotic Initiation Factor 2α

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12 December 2020

Free radical scavengers protect dopaminergic cell lines from apoptosis induced by complex I inhibitors

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12 December 2020

Neural heme oxygenase-1 expression in idiopathic Parkinson's disease

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12 December 2020

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

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12 December 2020

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

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12 December 2020

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

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12 December 2020

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

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12 December 2020

10.1523/JNEUROSCI.22-24-10690.2002

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758450&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758450&resulttype=core&format=json

12 May 2020

PubMed publication ID

12486162

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758450&resulttype=core&format=json