Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates. (Q40226743)

PubMed publication ID

17005870

18 September 2017

title

Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674486&resulttype=core&format=json

11 May 2020

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Joseph R Mazzulli

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674486&resulttype=core&format=json

11 May 2020

Amanda J Mishizen

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11 May 2020

Benoit I Giasson

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11 May 2020

David R Lynch

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11 May 2020

Steven A Thomas

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11 May 2020

Akira Nakashima

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11 May 2020

Toshiharu Nagatsu

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11 May 2020

Akira Ota

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11 May 2020

Harry Ischiropoulos

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11 May 2020

language of work or name

English

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publication date

1 September 2006

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PubMed publication ID

17005870

18 September 2017

published in

Journal of Neuroscience

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11 May 2020

volume

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11 May 2020

issue

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11 May 2020

page(s)

10068-10078

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Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro

11 May 2020

cites work

1 reference

12 December 2020

alpha-Synuclein shares physical and functional homology with 14-3-3 proteins

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Peroxynitrite inactivation of tyrosine hydroxylase: mediation by sulfhydryl oxidation, not tyrosine nitration.

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A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease

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Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

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Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies

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Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

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Epitope mapping of LB509, a monoclonal antibody directed against human alpha-synuclein

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Chaperone-like activity of synucleins

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Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease

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Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

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12 December 2020

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

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12 December 2020

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

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12 December 2020

alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells

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12 December 2020

alpha-Synuclein is phosphorylated in synucleinopathy lesions

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12 December 2020

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

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12 December 2020

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein

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12 December 2020

The mutation of two amino acid residues in the N-terminus of tyrosine hydroxylase (TH) dramatically enhances the catalytic activity in neuroendocrine AtT-20 cells

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Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases

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Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

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12 December 2020

Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

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12 December 2020

Parkinson's disease and related alpha-synucleinopathies are brain amyloidoses

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12 December 2020

Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications

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12 December 2020

Role of alpha-synuclein carboxy-terminus on fibril formation in vitro

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12 December 2020

Comparison of transfection conditions for a lentivirus vector produced in large volumes

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12 December 2020

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

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12 December 2020

Dopamine and L-dopa disaggregate amyloid fibrils: implications for Parkinson's and Alzheimer's disease

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12 December 2020

Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation.

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12 December 2020

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

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12 December 2020

Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation.

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12 December 2020

Parkinson's disease and dementia with Lewy bodies: a difference in dose?

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12 December 2020

The E46K mutation in alpha-synuclein increases amyloid fibril formation.

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12 December 2020

Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

1 reference

12 December 2020

Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations.

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12 December 2020

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

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12 December 2020

Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein.

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12 December 2020

Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

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12 December 2020

Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway

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12 December 2020

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

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12 December 2020

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12 December 2020

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

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12 December 2020

Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.

1 reference

12 December 2020

Change of tyrosine hydroxylase in the parkinsonian brain and in the brain of MPTP-treated mice as revealed by homospecific activity

1 reference

12 December 2020

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

1 reference

12 December 2020

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

1 reference

12 December 2020

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

1 reference

12 December 2020

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

12 December 2020

Alpha-synuclein in Lewy bodies

1 reference

12 December 2020

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

12 December 2020

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

1 reference

12 December 2020

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

1 reference

12 December 2020

Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

1 reference

12 December 2020

Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones

1 reference

12 December 2020

10.1523/JNEUROSCI.0896-06.2006

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674486&resulttype=core&format=json

11 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674486&resulttype=core&format=json

11 May 2020

PubMed publication ID

17005870

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674486&resulttype=core&format=json