Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794. (Q40140985)

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scientific article published on 25 April 2007

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English	Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794.	scientific article published on 25 April 2007

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794. (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

phosphorylation

1 reference

based on heuristic

inferred from title

apoptotic process

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based on heuristic

inferred from title

author name string

Alexandros Tzatsos

1

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Philip N Tsichlis

2

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

language of work or name

0 references

publication date

25 April 2007

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Europe PubMed Central

PubMed publication ID

17 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

17 September 2017

282

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

25

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

18069-18082

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

1 reference

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Rheb binds and regulates the mTOR kinase

1 reference

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TSC2 mediates cellular energy response to control cell growth and survival

1 reference

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

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AMP-activated protein kinase signaling in metabolic regulation

1 reference

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LKB1-dependent signaling pathways

1 reference

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Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

1 reference

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21 January 2018

The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases

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Function of mammalian LKB1 and Ca2+/calmodulin-dependent protein kinase kinase alpha as Snf1-activating kinases in yeast

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Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

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Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

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Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes.

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

1 reference

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Inflammation and insulin resistance

1 reference

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5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside

1 reference

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Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2

1 reference

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In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents

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Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

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Depletion of mitochondrial DNA causes impaired glucose utilization and insulin resistance in L6 GLUT4myc myocytes.

1 reference

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Hypoxia-induced energy stress regulates mRNA translation and cell growth

1 reference

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The regulation of AMP-activated protein kinase by H(2)O(2).

1 reference

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21 January 2018

Mammalian AMP-activated protein kinase subfamily

1 reference

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Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610101200

21 January 2018

Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load

1 reference

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21 January 2018

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

1 reference

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Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases

1 reference

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Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610101200

21 January 2018

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610101200

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Mitochondrial membrane dynamics, cristae remodelling and apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610101200

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Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

1 reference

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21 January 2018

5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments

1 reference

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21 January 2018

Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit

1 reference

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21 January 2018

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

1 reference

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21 January 2018

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

1 reference

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AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits

1 reference

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α2 isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-β-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal mu

1 reference

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Reactive oxygen species have a causal role in multiple forms of insulin resistance

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Dysregulation of the TSC-mTOR pathway in human disease

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5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase

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Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation

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21 January 2018

Identifiers

10.1074/JBC.M610101200

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

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