Dysregulation of the TSC-mTOR pathway in human disease (Q34380413)

1 August 2017

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title

Dysregulation of the TSC-mTOR pathway in human disease (English)

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1 August 2017

Ken Inoki

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1 August 2017

Michael N Corradetti

series ordinal

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1 August 2017

Kun-Liang Guan

series ordinal

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1 August 2017

language of work or name

English

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publication date

1 January 2005

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1 August 2017

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

19-24

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

1 August 2017

cites work

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7 January 2021

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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7 January 2021

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

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7 January 2021

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

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7 January 2021

Tor signalling in bugs, brain and brawn

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7 January 2021

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

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7 January 2021

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

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7 January 2021

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

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7 January 2021

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

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7 January 2021

The p70 S6 kinase integrates nutrient and growth signals to control translational capacity.

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7 January 2021

Synthesis of the translational apparatus is regulated at the translational level

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7 January 2021

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

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7 January 2021

eIF4E--from translation to transformation

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7 January 2021

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

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7 January 2021

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

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7 January 2021

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

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7 January 2021

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

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7 January 2021

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

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7 January 2021

Rheb promotes cell growth as a component of the insulin/TOR signalling network

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7 January 2021

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

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7 January 2021

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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7 January 2021

Akt regulates growth by directly phosphorylating Tsc2

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7 January 2021

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

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7 January 2021

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

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7 January 2021

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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7 January 2021

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

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7 January 2021

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

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7 January 2021

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

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7 January 2021

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

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7 January 2021

Mammalian TOR: a homeostatic ATP sensor

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7 January 2021

The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?

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7 January 2021

TSC2 mediates cellular energy response to control cell growth and survival

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7 January 2021

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

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7 January 2021

Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases

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7 January 2021

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

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7 January 2021

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

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7 January 2021

The LKB1 tumor suppressor negatively regulates mTOR signaling

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7 January 2021

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

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7 January 2021

Vacuolar import of proteins and organelles from the cytoplasm

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7 January 2021

Autophagy as a cell death and tumor suppressor mechanism

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7 January 2021

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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7 January 2021

National Cancer Institute Workshop Report: the phakomatoses revisited

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7 January 2021

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

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7 January 2021

Identification and characterization of the tuberous sclerosis gene on chromosome 16

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7 January 2021

Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions

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7 January 2021

Pathogenesis of hereditary tumors: beyond the "two-hit" hypothesis

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7 January 2021

Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma

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7 January 2021

Tuberous sclerosis: from tubers to mTOR.

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7 January 2021

Will mTOR inhibitors make it as cancer drugs?

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7 January 2021

PTEN: one gene, many syndromes

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7 January 2021

PTEN and myotubularin: novel phosphoinositide phosphatases

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7 January 2021

Germline PTEN promoter mutations and deletions in Cowden/Bannayan-Riley-Ruvalcaba syndrome result in aberrant PTEN protein and dysregulation of the phosphoinositol-3-kinase/Akt pathway

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7 January 2021

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

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7 January 2021

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

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7 January 2021

Colonic hamartomas in tuberous sclerosis

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7 January 2021

De novo germline mutation in the serine-threonine kinase STK11/LKB1 gene associated with Peutz-Jeghers syndrome

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7 January 2021

Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome

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7 January 2021

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

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7 January 2021

Tuberous sclerosis complex and neurofibromatosis type 1: the two most common neurocutaneous diseases

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7 January 2021

NF1 tumor suppressor gene function: narrowing the GAP

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7 January 2021

Ras is involved in the negative control of autophagy through the class I PI3-kinase

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7 January 2021

Roles of phosphatidylinositol 3'-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial cells

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7 January 2021

The von Hippel-Lindau Gene, Kidney Cancer, and Oxygen Sensing

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7 January 2021

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

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7 January 2021

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

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7 January 2021

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7 January 2021

AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression

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7 January 2021

The tuberin-hamartin complex negatively regulates beta-catenin signaling activity

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7 January 2021

Mutations in the SMAD4/DPC4 gene in juvenile polyposis

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7 January 2021

Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes

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7 January 2021

Constipation, polyps, or cancer? let PTEN predict your future

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7 January 2021

Tuberous sclerosis complex 2 gene product interacts with human SMAD proteins. A molecular link of two tumor suppressor pathways

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7 January 2021

BMPs signal alternately through a SMAD or FRAP-STAT pathway to regulate fate choice in CNS stem cells

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7 January 2021

BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling

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7 January 2021

Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex.

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7 January 2021

Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome

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7 January 2021

Lymphangioleiomyomatosis: a review of the literature

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7 January 2021

Searching for the hereditary causes of renal-cell carcinoma

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7 January 2021

A germ-line insertion in the Birt-Hogg-Dubé (BHD) gene gives rise to the Nihon rat model of inherited renal cancer

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7 January 2021

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

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7 January 2021

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

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7 January 2021

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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7 January 2021

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

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7 January 2021

Rapamycin attenuates load-induced cardiac hypertrophy in mice

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7 January 2021

Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis

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7 January 2021

Identification of a gene responsible for familial Wolff-Parkinson-White syndrome

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7 January 2021

Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome.

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7 January 2021

Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte

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7 January 2021

Immunopharmacology of rapamycin

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7 January 2021

Can we prevent in-stent restenosis?

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7 January 2021

Targeting mTOR signaling for cancer therapy

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7 January 2021

The TOR pathway: a target for cancer therapy

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7 January 2021

Identifiers

DOI

10.1038/NG1494

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1 August 2017

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