A small molecule inhibitor of Rheb selectively targets mTORC1 signaling. (Q49198717)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29416044%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

title

A small molecule inhibitor of Rheb selectively targets mTORC1 signaling (English)

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14 March 2020

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14 March 2020

Sridhar Narayan

1 reference

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14 March 2020

Lisa Molz

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14 March 2020

Lauren A Berstler

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14 March 2020

Seong A Kang

1 reference

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14 March 2020

George P Vlasuk

1 reference

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14 March 2020

Eddine Saiah

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14 March 2020

language of work or name

English

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publication date

7 February 2018

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14 March 2020

published in

Nature Communications

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14 March 2020

volume

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14 March 2020

issue

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14 March 2020

page(s)

548

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Creative Commons Attribution 4.0 International

14 March 2020

start time

7 February 2018

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April 2022 Public Data File from Crossref

copyrighted

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cites work

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The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

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22 May 2018

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Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells

22 May 2018

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22 May 2018

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Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.

22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

22 May 2018

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Inhibition of Ras for cancer treatment: the search continues

22 May 2018

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mTOR inhibitors in renal cell carcinoma

22 May 2018

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mTOR complex 2 signaling and functions

22 May 2018

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The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

22 May 2018

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Rheb is essential for murine development

22 May 2018

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mTOR: from growth signal integration to cancer, diabetes and ageing

22 May 2018

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Ras Homolog Enriched in Brain (Rheb) Enhances Apoptotic Signaling

22 May 2018

1 reference

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mTOR signaling: a central pathway to pathogenesis in systemic lupus erythematosus?

22 May 2018

1 reference

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Therapeutic targeting of mTOR in tuberous sclerosis

22 May 2018

1 reference

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

22 May 2018

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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

22 May 2018

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mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation

22 May 2018

1 reference

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Affinity selection-mass spectrometry screening techniques for small molecule drug discovery

22 May 2018

1 reference

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The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803267

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803267

The mTOR pathway in the control of protein synthesis

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803267

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803267

The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803267

The Ras superfamily at a glance

22 May 2018

1 reference

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Structural basis for the unique biological function of small GTPase RHEB

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803267

Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803267

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803267

Tuberous sclerosis complex (TSC) gene involvement in sporadic tumours

22 May 2018

1 reference

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NMR spectroscopy techniques for screening and identifying ligand binding to protein receptors

22 May 2018

1 reference

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Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.

22 May 2018

1 reference

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Safety and tolerability of AZD8055 in Japanese patients with advanced solid tumors; a dose-finding phase I study.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803267

Long-term administration of rapamycin reduces adiposity, but impairs glucose tolerance in high-fat diet-fed KK/HlJ mice.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803267

Diabetes after transplantation and sirolimus: what's the connection?

14 August 2018

1 reference

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mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5803267

Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways

14 August 2018

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New tricks for human farnesyltransferase inhibitor: cancer and beyond

14 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41467-018-03035-Z

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/S41467-018-03035-Z

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29416044%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

14 March 2020

ADS bibcode

2018NatCo...9..548M

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1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29416044%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

PubMed publication ID

29416044

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29416044%20AND%20SRC:MED&resulttype=core&format=json