Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts (Q35058634)

24303063

6 August 2017

title

Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts (English)

1 reference

6 August 2017

1 reference

1 reference

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10 June 2020

Marlous J Groenewoud

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24303063%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Susan M I Goorden

1 reference

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10 June 2020

Jorien Kassies

1 reference

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10 June 2020

Wendy Pellis-van Berkel

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24303063%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Richard F Lamb

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24303063%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Fried J T Zwartkruis

1 reference

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10 June 2020

language of work or name

English

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publication date

26 November 2013

1 reference

6 August 2017

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10 June 2020

volume

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10 June 2020

issue

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10 June 2020

page(s)

e81649

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Creative Commons Attribution 3.0 Unported

10 June 2020

start time

26 November 2013

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April 2022 Public Data File from Crossref

copyrighted

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describes a project that uses

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3841147/fullTextXML

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inferred from PubMed Central ID database lookup

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ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).

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mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

8 July 2018

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8 July 2018

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Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation

8 July 2018

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Differential regulation of NHE1 phosphorylation and glucose uptake by inhibitors of the ERK pathway and p90RSK in 3T3-L1 adipocytes

8 July 2018

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Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR.

8 July 2018

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Molecular mechanisms of mTOR-mediated translational control

8 July 2018

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

8 July 2018

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Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition

8 July 2018

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

8 July 2018

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Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration

8 July 2018

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

8 July 2018

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Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation

8 July 2018

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Regulation of TORC1 by Rag GTPases in nutrient response

8 July 2018

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

8 July 2018

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

8 July 2018

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Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.

8 July 2018

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The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

8 July 2018

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

8 July 2018

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

8 July 2018

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

8 July 2018

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Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase

8 July 2018

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Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1

8 July 2018

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

8 July 2018

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Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways

8 July 2018

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Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3841147

Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3841147

Rheb binds and regulates the mTOR kinase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3841147

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3841147

Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3841147

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3841147

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3841147

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3841147

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3841147

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

8 July 2018

1 reference

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3841147

Rheb promotes cell growth as a component of the insulin/TOR signalling network

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3841147

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3841147

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3841147

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3841147

Identification of a conserved motif required for mTOR signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3841147

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3841147

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3841147

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3841147

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

8 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0081649

S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0081649

Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0081649

TORC1-dependent epilepsy caused by acute biallelic Tsc1 deletion in adult mice.

21 January 2018

1 reference

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Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by

25 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24303063

inferred from PubMed ID database lookup

12 December 2020

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Identifiers

DOI

10.1371/JOURNAL.PONE.0081649

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24303063%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

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24 November 2022

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24303063%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

24303063

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