In vitro systems: current limitations and future perspectives (Q48722295)

15 February 2018

editorial

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title

In vitro systems: current limitations and future perspectives (English)

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15 February 2018

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15 February 2018

author name string

H M Bolt

series ordinal

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15 February 2018

publication date

5 November 2014

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15 February 2018

published in

Archives of Toxicology

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15 February 2018

volume

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15 February 2018

issue

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15 February 2018

page(s)

2085-2087

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15 February 2018

Modulation of cytochrome P450 1 (Cyp1) by vanadium in hepatic tissue and isolated hepatocyte of C57BL/6 mice.

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Developmental neurotoxicity testing with human embryonic stem cell-derived in vitro systems: the novel FP7 ESNATS tests are available

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Mouse hepatoma cell lines differing in aryl hydrocarbon receptor-mediated signaling have different activities for glucuronidation

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Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells.

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Manganese-exposed developing rats display motor deficits and striatal oxidative stress that are reversed by Trolox

21 January 2018

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The risky cocktail: what combination effects can we expect between ecstasy and other amphetamines?

21 January 2018

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The role of residues T248, Y249 and T422 in the function of human pregnane X receptor

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Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling.

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Repeat oral dose toxicity studies of melamine in rats and monkeys

21 January 2018

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Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies

21 January 2018

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Differentiation and selection of hepatocyte precursors in suspension spheroid culture of transgenic murine embryonic stem cells

21 January 2018

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Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis

21 January 2018

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Reversible manipulation of apoptosis sensitivity in cultured hepatocytes by matrix-mediated manipulation of signaling activities.

21 January 2018

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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

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21 January 2018

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High fidelity neuronal networks formed by plasma masking with a bilayer membrane: analysis of neurodegenerative and neuroprotective processes

21 January 2018

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In vitro - in vivo correlation of gene expression alterations induced by liver carcinogens.

21 January 2018

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Multidrug resistance-associated proteins are involved in the transport of the glutathione conjugates of the ultimate carcinogen of benzo[a]pyrene in human Caco-2 cells.

21 January 2018

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A 3-dimensional human embryonic stem cell (hESC)-derived model to detect developmental neurotoxicity of nanoparticles.

21 January 2018

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Augmenter of liver regeneration causes different kinetics of ERK1/2 and Akt/PKB phosphorylation than EGF and induces hepatocyte proliferation in an EGF receptor independent and liver specific manner

21 January 2018

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Augmenter of liver regeneration (ALR) protects human hepatocytes against apoptosis.

21 January 2018

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Fluorescence-based recombination assay for sensitive and specific detection of genotoxic carcinogens in human cells

21 January 2018

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EMT and CSC-like properties mediated by the IKKβ/IκBα/RelA signal pathway via the transcriptional regulator, Snail, are involved in the arsenite-induced neoplastic transformation of human keratinocytes

21 January 2018

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Utility of in vitro systems and preclinical data for the prediction of human intestinal first-pass metabolism during drug discovery and preclinical development.

21 January 2018

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Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants.

21 January 2018

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Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach

21 January 2018

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Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice

21 January 2018

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Apoptosis initiation of β-ionone in SGC-7901 gastric carcinoma cancer cells via a PI3K-AKT pathway

21 January 2018

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Multi-cell type human liver microtissues for hepatotoxicity testing

21 January 2018

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Distinct role of endocytosis for Smad and non-Smad TGF-β signaling regulation in hepatocytes.

21 January 2018

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Apoptosis induced by trimethyltin chloride in human neuroblastoma cells SY5Y is regulated by a balance and cross-talk between NF-κB and MAPKs signaling pathways

21 January 2018

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Metallothionein blocks oxidative DNA damage in vitro.

21 January 2018

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The impact of FANCD2 deficiency on formaldehyde-induced toxicity in human lymphoblastoid cell lines

21 January 2018

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Hepatotumorigenicity of ethyl tertiary-butyl ether with 2-year inhalation exposure in F344 rats

21 January 2018

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Zebrafish embryos as an alternative model for screening of drug-induced organ toxicity

21 January 2018

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Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes

21 January 2018

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Hepatic 3D cultures but not 2D cultures preserve specific transporter activity for acetaminophen-induced hepatotoxicity

21 January 2018

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Decrease of global methylation improves significantly hepatic differentiation of Ad-MSCs: possible future application for urea detoxification

21 January 2018

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In vitro metabolism of the anti-androgenic fungicide vinclozolin by rat liver microsomes

21 January 2018

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HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved.

21 January 2018

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Assessment of ABCG2-mediated transport of xenobiotics across the blood-milk barrier of dairy animals using a new MDCKII in vitro model

21 January 2018

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Toxicokinetics of acrylamide in primary rat hepatocytes: coupling to glutathione is faster than conversion to glycidamide

21 January 2018

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Resveratrol protects against arsenic trioxide-induced nephrotoxicity by facilitating arsenic metabolism and decreasing oxidative stress

21 January 2018

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Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes.

21 January 2018

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10.1007/S00204-014-1404-6

21 January 2018

Identifiers

DOI

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15 February 2018

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15 February 2018