Leptin accelerates the pathogenesis of heterotopic ossification in rat tendon tissues via mTORC1 signaling (Q48278243)

10 February 2018

title

Leptin accelerates the pathogenesis of heterotopic ossification in rat tendon tissues via mTORC1 signaling (English)

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10 February 2018

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Cory J. Xian

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author name string

Huaji Jiang

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Yuhui Chen

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Guorong Chen

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Xinggui Tian

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Jiajun Tang

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Lei Luo

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Minjun Huang

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Bin Yan

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Xiang Ao

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Wen Zhou

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Xiaochun Bai

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Zhongmin Zhang

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Liang Wang

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publication date

13 April 2017

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Journal of Cellular Physiology

published in

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volume

233

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issue

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page(s)

1017-1028

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Diminished Chondrogenesis and Enhanced Osteoclastogenesis in Leptin-Deficient Diabetic Mice (ob/ob) Impair Pathologic, Trauma-Induced Heterotopic Ossification

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Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification

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The expanding relevance of nuclear mTOR in carcinogenesis

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Early changes in prostaglandins precede bone formation in a rabbit model of heterotopic ossification

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Leptin regulates chondrogenic differentiation in ATDC5 cell-line through JAK/STAT and MAPK pathways

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Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche.

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mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis

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Adipose-derived stem cells sustain prolonged angiogenesis through leptin secretion.

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Differences between perivascular adipose tissue surrounding the heart and the internal mammary artery: possible role for the leptin-inflammation-fibrosis-hypoxia axis.

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Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation.

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Sixteen years and counting: an update on leptin in energy balance

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Stem cells for augmenting tendon repair

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Leptin increases extracellular matrix mineralization of human osteoblasts from heterotopic ossification and normal bone

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Rapamycin affects early fracture healing in mice

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Association between serum leptin and bone metabolic markers, and the development of heterotopic ossification of the spinal ligament in female patients with ossification of the posterior longitudinal ligament

21 January 2018

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Rapamycin as an inhibitor of osteogenic differentiation in bone marrow-derived mesenchymal stem cells

21 January 2018

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Leptin effect on RANKL and OPG expression in MC3T3-E1 osteoblasts

21 January 2018

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Leptin-induced transphosphorylation of vascular endothelial growth factor receptor increases Notch and stimulates endothelial cell angiogenic transformation

21 January 2018

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Mechanical Tension Promotes the Osteogenic Differentiation of Rat Tendon-derived Stem Cells Through the Wnt5a/Wnt5b/JNK Signaling Pathway.

21 January 2018

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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mTOR inactivation in myocardium from infant mice rapidly leads to dilated cardiomyopathy due to translation defects and p53/JNK-mediated apoptosis.

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Activation of GLP-1 Receptor Promotes Bone Marrow Stromal Cell Osteogenic Differentiation through β-Catenin

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Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression

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The impact of class III (morbid) obesity on heterotopic ossification outcomes.

21 January 2018

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Histone deacetylase inhibition with valproic acid downregulates osteocalcin gene expression in human dental pulp stem cells and osteoblasts: evidence for HDAC2 involvement.

21 January 2018

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Role of gender in burn-induced heterotopic ossification and mesenchymal cell osteogenic differentiation

21 January 2018

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The effects of COX-1 and COX-2 inhibitors on prostaglandin synthesis and the formation of heterotopic bone in a rat model

21 January 2018

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Uniaxial mechanical tension promoted osteogenic differentiation of rat tendon-derived stem cells (rTDSCs) via the Wnt5a-RhoA pathway

21 January 2018

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Rapamycin inhibits osteoblast proliferation and differentiation in MC3T3-E1 cells and primary mouse bone marrow stromal cells

21 January 2018

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Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling

21 January 2018

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EGR1 induces tenogenic differentiation of tendon stem cells and promotes rabbit rotator cuff repair.

21 January 2018

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Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production

21 January 2018

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Activation of IL-8 via PI3K/Akt-dependent pathway is involved in leptin-mediated epithelial-mesenchymal transition in human breast cancer cells

21 January 2018

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Leptin exerts proliferative and anti-apoptotic effects on goose granulosa cells through the PI3K/Akt/mTOR signaling pathway.

21 January 2018

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Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

21 January 2018

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Leptin promotes VEGF-C production and induces lymphangiogenesis by suppressing miR-27b in human chondrosarcoma cells

21 January 2018

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Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow.

21 January 2018

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Effects of celecoxib on proliferation and tenocytic differentiation of tendon-derived stem cells

21 January 2018

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Increased osteogenesis in osteoporotic bone marrow stromal cells by overexpression of leptin

21 January 2018

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Echinomycin in the prevention of heterotopic ossification - an experimental antibiotic agent shows promising results in a murine model.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCP.25955

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10 February 2018

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10 February 2018