mTOR inactivation in myocardium from infant mice rapidly leads to dilated cardiomyopathy due to translation defects and p53/JNK-mediated apoptosis. (Q53110486)

From Wikidata

Jump to navigation Jump to search

scientific article published on 28 April 2016

Language	Label	Description	Also known as
English	mTOR inactivation in myocardium from infant mice rapidly leads to dilated cardiomyopathy due to translation defects and p53/JNK-mediated apoptosis.	scientific article published on 28 April 2016

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/27133769

mTOR inactivation in myocardium from infant mice rapidly leads to dilated cardiomyopathy due to translation defects and p53/JNK-mediated apoptosis. (English)

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/27133769

dilated cardiomyopathy

1 reference

based on heuristic

inferred from title

Laetitia Mazelin

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Valérie Risson

8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Genevieve Derumeaux

11

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Daniel Taillandier

12

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Théophile Ohlmann

13

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Yann-Gaël Gangloff

15

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

author name string

Baptiste Panthu

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Anne-Sophie Nicot

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Edwige Belotti

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Lionel Tintignac

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Geoffrey Teixeira

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Qing Zhang

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Dominique Baas

9

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Emilie Delaune

10

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Michel Ovize

14

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Laurent Schaeffer

16

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

publication date

28 April 2016

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/27133769

Journal of Molecular and Cellular Cardiology

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

97

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

213-225

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Molecular basis of physiological heart growth: fundamental concepts and new players

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Akt/protein kinase B promotes organ growth in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

mTOR signaling in cellular and organismal energetics

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

mTOR signaling in growth control and disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Molecular mechanisms of mTOR-mediated translational control

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Anti-remodeling effects of rapamycin in experimental heart failure: dose response and interaction with angiotensin receptor blockade

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Phosphoinositide-dependent kinase 1 and mTORC2 synergistically maintain postnatal heart growth and heart function in mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

mTORC2 regulates cardiac response to stress by inhibiting MST1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Characterization and analysis of the composition and dynamics of the mammalian riboproteome.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

In vitro translation in a hybrid cell free lysate with exogenous cellular ribosomes

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

In vitro translation of mRNAs that are in their native ribonucleoprotein complexes

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Effects of 4E-BP1 expression on hypoxic cell cycle inhibition and tumor cell proliferation and survival

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

eIF4E knockdown decreases breast cancer cell growth without activating Akt signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Upregulation of Bcl-2 proteins during the transition to pressure overload-induced heart failure.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

STRESS signaling pathways that modulate cardiac myocyte apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

MEKK1/JNK signaling stabilizes and activates p53.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Induction of Ankrd1 in Dilated Cardiomyopathy Correlates with the Heart Failure Progression

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Overexpression of ankyrin repeat domain 1 enhances cardiomyocyte apoptosis by promoting p53 activation and mitochondrial dysfunction in rodents

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Adaptive mechanisms that preserve cardiac function in mice without myoglobin

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Pifithrin-alpha attenuates p53-mediated apoptosis and improves cardiac function in response to myocardial ischemia/reperfusion in aged rats

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Pifithrin-alpha protects against doxorubicin-induced apoptosis and acute cardiotoxicity in mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Inhibition of p53 after acute myocardial infarction: reduction of apoptosis is counteracted by disturbed scar formation and cardiac rupture

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Regulation of p53 by jagged1 contributes to angiotensin II-induced impairment of myocardial angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

A unifying model for mTORC1-mediated regulation of mRNA translation.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Cardiac ablation of Rheb1 induces impaired heart growth, endoplasmic reticulum-associated apoptosis and heart failure in infant mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Ca2+/calmodulin-dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Acute doxorubicin cardiotoxicity is associated with p53-induced inhibition of the mammalian target of rapamycin pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Loss of Mdm4 results in p53-dependent dilated cardiomyopathy.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Cytoplasmic functions of the tumour suppressor p53.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Activation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemia

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2016.04.011

7 January 2021

Identifiers

10.1016/J.YJMCC.2016.04.011

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27133769%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q53110486&oldid=1517725981"