Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity (Q48143208)

9 February 2018

http://europepmc.org/abstract/MED/27457813

title

Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity (English)

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9 February 2018

http://europepmc.org/abstract/MED/27457813

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11 June 2020

M J Kim

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D M Fass

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11 June 2020

M C Lewis

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Q Zhang

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M Fleishman

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M Machius

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M Fromer

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S M Purcell

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S A McCarroll

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11 June 2020

G Rudenko

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E M Scolnick

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S J Haggarty

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11 June 2020

language of work or name

English

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publication date

26 July 2016

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9 February 2018

http://europepmc.org/abstract/MED/27457813

published in

Molecular Psychiatry

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11 June 2020

volume

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issue

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11 June 2020

page(s)

417-429

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describes a project that uses

11 June 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

cites work

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GIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin II and epidermal growth factor

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Biological insights from 108 schizophrenia-associated genetic loci

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Dlx1 transcription factor regulates dendritic growth and postsynaptic differentiation through inhibition of neuropilin-2 and PAK3 expression

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Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia

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A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins

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Identification of phosphorylation sites in GIT1.

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Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice

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FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism

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beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein

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Synapse formation is regulated by the signaling adaptor GIT1

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12 December 2020

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

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12 December 2020

GIT1 Paxillin-binding Domain Is a Four-helix Bundle, and It Binds to Both Paxillin LD2 and LD4 Motifs

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12 December 2020

A novel splice mutation in PAK3 gene underlying mental retardation with neuropsychiatric features

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12 December 2020

GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration

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Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting

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p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties

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12 December 2020

Mechanistic Insights into Regulated Cargo Binding by ACAP1 Protein

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De novo mutations in schizophrenia implicate synaptic networks

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The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus

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12 December 2020

Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation

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12 December 2020

Sequential implication of the mental retardation proteins ARHGEF6 and PAK3 in spine morphogenesis

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12 December 2020

Regulation of neuroendocrine exocytosis by the ARF6 GTPase-activating protein GIT1

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12 December 2020

A tissue-specific atlas of mouse protein phosphorylation and expression

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12 December 2020

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

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12 December 2020

Gene expression and genetic variation data implicate PCLO in bipolar disorder

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GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin

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A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC

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12 December 2020

Genetic architectures of psychiatric disorders: the emerging picture and its implications

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12 December 2020

Regulation of AMPA receptor subunit GluA1 surface expression by PAK3 phosphorylation

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The p21-activated kinase 3 implicated in mental retardation regulates spine morphogenesis through a Cdc42-dependent pathway

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12 December 2020

The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism

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12 December 2020

Alterations in cortical network oscillations and parvalbumin neurons in schizophrenia

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12 December 2020

GIT1 and βPIX are essential for GABA(A) receptor synaptic stability and inhibitory neurotransmission.

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12 December 2020

A polygenic burden of rare disruptive mutations in schizophrenia

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12 December 2020

Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3.

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12 December 2020

PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation

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12 December 2020

Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly

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12 December 2020

Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits

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12 December 2020

X-linked mild non-syndromic mental retardation with neuropsychiatric problems and the missense mutation A365E in PAK3.

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12 December 2020

PROMALS3D: multiple protein sequence alignment enhanced with evolutionary and three-dimensional structural information

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12 December 2020

The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo

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12 December 2020

Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies

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12 December 2020

Support for the N -Methyl-D-Aspartate Receptor Hypofunction Hypothesis of Schizophrenia From Exome Sequencing in Multiplex Families

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12 December 2020

GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice

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12 December 2020

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

1 reference

12 December 2020

The NMDA receptor 'glycine modulatory site' in schizophrenia: D-serine, glycine, and beyond

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12 December 2020

Presynaptic Deletion of GIT Proteins Results in Increased Synaptic Strength at a Mammalian Central Synapse

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Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour

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12 December 2020

Identifiers

DOI

10.1038/MP.2016.98

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27457813%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27457813%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27457813%20AND%20SRC:MED&resulttype=core&format=json