Control of mitochondrial integrity in Parkinson's disease (Q48095146)

8 February 2018

title

Control of mitochondrial integrity in Parkinson's disease (English)

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8 February 2018

1 reference

Serge Przedborski

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8 February 2018

Vernice Jackson-Lewis

object named as

Vernice Jackson-Lewis

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8 February 2018

author name string

Cristofol Vives-Bauza

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8 February 2018

Maja Tocilescu

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8 February 2018

Rosa L A Devries

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8 February 2018

Dana M Alessi

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8 February 2018

publication date

1 January 2010

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8 February 2018

Progress in Brain Research

published in

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8 February 2018

volume

183

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8 February 2018

page(s)

99-113

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8 February 2018

OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

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Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease

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GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin

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7 January 2021

Mitochondria: dynamic organelles in disease, aging, and development

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7 January 2021

Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology.

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7 January 2021

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

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7 January 2021

Selective mitochondrial autophagy during erythroid maturation

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7 January 2021

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

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7 January 2021

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

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Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death

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7 January 2021

Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission

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7 January 2021

Parkinson's disease: mechanisms and models

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7 January 2021

Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

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7 January 2021

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

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7 January 2021

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

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7 January 2021

Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

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7 January 2021

Evidence that Wallerian degeneration and localized axon degeneration induced by local neurotrophin deprivation do not involve caspases

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7 January 2021

Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis

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7 January 2021

The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells

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7 January 2021

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

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7 January 2021

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

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7 January 2021

Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent

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7 January 2021

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

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7 January 2021

High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy

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7 January 2021

Mitochondria and Ca(2+) signaling: old guests, new functions

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7 January 2021

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

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7 January 2021

Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential

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7 January 2021

The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses.

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7 January 2021

Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis

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7 January 2021

CaM kinase I alpha-induced phosphorylation of Drp1 regulates mitochondrial morphology

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7 January 2021

Molecular motors in neuronal development, intracellular transport and diseases

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7 January 2021

The axonal transport of mitochondria.

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7 January 2021

Selective degradation of mitochondria by mitophagy

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7 January 2021

Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

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7 January 2021

Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

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7 January 2021

Dopamine covalently modifies and functionally inactivates parkin

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7 January 2021

Myosin-V, a versatile motor for short-range vesicle transport

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7 January 2021

Parkinson's disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

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7 January 2021

Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis

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7 January 2021

The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses

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7 January 2021

Mitochondria mass is low in mouse substantia nigra dopamine neurons: implications for Parkinson's disease

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7 January 2021

Movement of mitochondria in the axons and dendrites of cultured hippocampal neurons

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7 January 2021

Characterization of PINK1 processing, stability, and subcellular localization

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7 January 2021

Effects of paraquat on the substantia nigra of the wistar rats: neurochemical, histological, and behavioral studies

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7 January 2021

Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses.

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7 January 2021

Separate fusion of outer and inner mitochondrial membranes.

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7 January 2021

Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Mitochondrial fusion intermediates revealed in vitro

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Nix is a selective autophagy receptor for mitochondrial clearance

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process.

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

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7 January 2021

Mitochondrial ND5 mutations in idiopathic Parkinson's disease

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7 January 2021

Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA

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7 January 2021

Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

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7 January 2021

Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

What have PINK1 and HtrA2 genes told us about the role of mitochondria in Parkinson's disease?

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7 January 2021

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

The PINK1/Parkin pathway regulates mitochondrial morphology

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7 January 2021

Axonal self-destruction and neurodegeneration

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7 January 2021

Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae

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7 January 2021

Fate of nigrostriatal neurons in young mature mice given 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: a neurochemical and morphological reassessment

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7 January 2021

Paradigm lost: milton connects kinesin heavy chain to miro on mitochondria.

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7 January 2021

Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes

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7 January 2021

Genetic variation of Omi/HtrA2 and Parkinson's disease

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7 January 2021

Mitochondrial morphology is dynamic and varied

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7 January 2021

Essential role for Nix in autophagic maturation of erythroid cells

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7 January 2021

Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase

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7 January 2021

Immune surveillance via self digestion

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7 January 2021

NIX is required for programmed mitochondrial clearance during reticulocyte maturation

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7 January 2021

Mitochondrial dynamics and division in budding yeast

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7 January 2021

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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7 January 2021

Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls

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7 January 2021

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7 January 2021

The mitochondrial gateway to cell death

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Axonal transport of mitochondria to synapses depends on milton, a novel Drosophila protein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Mitochondrial dynamics and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Cellular integrity plus: organelle-related and protein-targeting functions of intermediate filaments.

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7 January 2021

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view

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7 January 2021

Parkin ubiquitinates and promotes the degradation of RanBP2

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Cytoplasmic dynein regulates the subcellular distribution of mitochondria by controlling the recruitment of the fission factor dynamin-related protein-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

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7 January 2021

PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c.

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility

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https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

A lethal defect of mitochondrial and peroxisomal fission

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Re-evaluation of the dysfunction of mitochondrial respiratory chain in skeletal muscle of patients with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Mitochondria are selectively eliminated from eukaryotic cells after blockade of caspases during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Parkin stabilizes microtubules through strong binding mediated by three independent domains.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

NIX induces mitochondrial autophagy in reticulocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983006-7

7 January 2021

10.1016/S0079-6123(10)83006-7

Identifiers

DOI

1 reference

8 February 2018

1 reference

8 February 2018