Downstream signalling events regulated by phosphatidylinositol 3-kinase activity (Q48002873)

7 February 2018

review article

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title

Downstream signalling events regulated by phosphatidylinositol 3-kinase activity (English)

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7 February 2018

author name string

Duronio V

series ordinal

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7 February 2018

Scheid MP

series ordinal

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7 February 2018

Ettinger S

series ordinal

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7 February 2018

publication date

1 April 1998

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7 February 2018

published in

Cellular Signalling

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7 February 2018

volume

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7 February 2018

issue

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7 February 2018

page(s)

233-239

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7 February 2018

Phosphatidylinositol 3-kinase

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Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain

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The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

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Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil

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Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

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On the mechanism of cytosolic phospholipase A2 activation in CHO cells carrying somatostatin receptor: wortmannin-sensitive pathway to activate mitogen-activated protein kinase

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Phosphatidylinositol 3-OH kinase activity is not required for activation of mitogen-activated protein kinase by cytokines

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Wortmannin inhibits mitogen-activated protein kinase activation by platelet-activating factor through a mechanism independent of p85/p110-type phosphatidylinositol 3-kinase

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Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase.

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1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells

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Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase

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A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity

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PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

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When is a lipid kinase not a lipid kinase? When it is a protein kinase

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Phosphatidylinositol 3-kinase related kinases

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Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase

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The PI3-kinase serine kinase phosphorylates its p85 subunit and IRS-1 in PI3-kinase/IRS-1 complexes

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Protein kinase C isoenzymes: divergence in signal transduction?

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Activation of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate

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Activation of PRK1 by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. A comparison with protein kinase C isotypes

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Phosphatidylinositol (3,4,5)-trisphosphate stimulates phosphorylation of pleckstrin in human platelets

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Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase

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Protein kinase C delta specifically associates with phosphatidylinositol 3-kinase following cytokine stimulation

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Association of phosphatidylinositol 3 kinase to protein kinase C zeta during interleukin-2 stimulation

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Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

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Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

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Molecular cloning of a second form of rac protein kinase

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A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

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A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

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AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation

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The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase

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Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2

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p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity

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Synaptojanin is the major constitutively active phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase in rodent brain.

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Mechanism of activation of protein kinase B by insulin and IGF-1

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Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

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7 January 2021

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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7 January 2021

Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase

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7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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7 January 2021

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

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7 January 2021

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

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7 January 2021

Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating

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Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

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7 January 2021

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

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Role of phosphatidylinositol-3-kinase in insulin receptor signaling: studies with inhibitor, LY294002.

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7 January 2021

Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites

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7 January 2021

Selective Inhibition of p70 S6 Kinase Activation by Phosphatidylinositol 3‐Kinase Inhibitors

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7 January 2021

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation

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Specific activation of p85-p110 phosphatidylinositol 3'-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways

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Normal Activation of P70 S6 Kinase by Insulin in Cells Overexpressing Dominant Negative 85-kDa Subunit of Phosphoinositide 3-Kinase

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7 January 2021

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity

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7 January 2021

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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7 January 2021

TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin

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7 January 2021

The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

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Role of p70 S6 kinase in cytokine-regulated hemopoietic cell survival

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Inhibition of the Phosphatidylinositol 3-Kinase/p70S6-Kinase Pathway Induces B16 Melanoma Cell Differentiation

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7 January 2021

Phosphatidylinositol 3-kinase and p70 s6 kinase participate in the regulation of protein turnover in skeletal muscle by insulin and insulin-like growth factor I

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7 January 2021

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

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7 January 2021

Phosphoinositide 3-kinase as an upstream regulator of the small GTP-binding protein Rac in the insulin signaling of membrane ruffling

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7 January 2021

Rho, rac and cdc42 GTPases: regulators of actin structures, cell adhesion and motility

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Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

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Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

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7 January 2021

Physical association and functional relationship between protein kinase Cζ and the actin cytoskeleton

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7 January 2021

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

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7 January 2021

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

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7 January 2021

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

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7 January 2021

10.1016/S0898-6568(97)00129-0

Identifiers

DOI

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7 February 2018

1 reference

7 February 2018