Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells (Q47631646)

4 February 2018

title

Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells (English)

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4 February 2018

Christophe Benoist

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4 February 2018

author name string

Tetsuya Yamagata

series ordinal

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4 February 2018

Diane Mathis

series ordinal

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4 February 2018

language of work or name

English

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publication date

9 May 2004

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4 February 2018

published in

Nature Immunology

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4 February 2018

volume

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4 February 2018

issue

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4 February 2018

page(s)

597-605

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4 February 2018

T-cell development and the CD4-CD8 lineage decision

cites work

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Evidence for a differential avidity model of T cell selection in the thymus

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The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells

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Positive selection of CD4(+) T cells is induced in vivo by agonist and inhibited by antagonist peptides

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The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families

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A modification of Jerne's theory of antibody production using the concept of clonal selection

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The thymus selects the useful, neglects the useless and destroys the harmful

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Projection of an immunological self shadow within the thymus by the aire protein

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MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus

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The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate

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Selection of intraepithelial lymphocytes with CD8 alpha/alpha co-receptors by self-antigen in the murine gut

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An opposite pattern of selection of a single T cell antigen receptor in the thymus and among intraepithelial lymphocytes

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Down-Modulation of CD8 β-Chain in Response to an Altered Peptide Ligand Enables Developing Thymocytes to Escape Negative Selection

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Early deletion and late positive selection of T cells expressing a male-specific receptor in T-cell receptor transgenic mice

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Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules

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Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

21 January 2018

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The effects of MHC gene dosage and allelic variation on T cell receptor selection

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Summaries of Affymetrix GeneChip probe level data

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Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis.

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Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2.

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The role of chemokines in linking innate and adaptive immunity

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Xanthine oxidoreductase is central to the evolution and function of the innate immune system

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Transcriptional profiling identifies Id2 function in dendritic cell development

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Autoreactivity by design: innate B and T lymphocytes

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The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells.

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Failure of HY-Specific Thymocytes to Escape Negative Selection by Receptor Editing

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Molecular coordination of alphabeta T-cell receptors and coreceptors CD8 and CD4 in their recognition of peptide-MHC ligands

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E2A Deficiency Leads to Abnormalities in αβ T-Cell Development and to Rapid Development of T-Cell Lymphomas

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Selective absence of CD8+ TCRalpha beta+ intestinal epithelial cells in transgenic mice expressing beta2-microglobulin-associated ligands exclusively on thymic cortical epithelium

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Stress management: MHC class I and class I-like molecules as reporters of cellular stress

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Structure and function of natural killer cell receptors: multiple molecular solutions to self, nonself discrimination.

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Expression and function of NK cell receptors in CD8+ T cells

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Biological insights into TCRgammadelta+ and TCRalphabeta+ intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE).

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Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

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Positive and negative thymocyte selection induced by different concentrations of a single peptide

21 January 2018

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7 January 2021

Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells

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7 January 2021

Immunological function of a defined T-cell population tolerized to low-affinity self antigens

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7 January 2021

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

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7 January 2021

Origin of regulatory T cells with known specificity for antigen

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7 January 2021

Precursors of functional MHC class I- or class II-restricted CD8alphaalpha(+) T cells are positively selected in the thymus by agonist self-peptides

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7 January 2021

Agonist peptide modulates T cell selection thresholds through qualitative and quantitative shifts in CD8 co-receptor expression

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7 January 2021

Ligand-specific selection of MHC class II-restricted thymocytes in fetal thymic organ culture

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7 January 2021

The Ets-1 transcription factor is required for the development of natural killer cells in mice

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7 January 2021

Identifiers

DOI

10.1038/NI1070

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4 February 2018

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4 February 2018