Duodenal HFE expression and hepcidin levels determine body iron homeostasis: modulation by genetic diversity and dietary iron availability (Q47404090)

15 January 2018

title

Duodenal HFE expression and hepcidin levels determine body iron homeostasis: modulation by genetic diversity and dietary iron availability (English)

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author name string

Susanne Ludwiczek

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Igor Theurl

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Erika Artner-Dworzak

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Michael Chorney

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publication date

13 May 2004

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Journal of Molecular Medicine

published in

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volume

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issue

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page(s)

373-382

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The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

cites work

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12 December 2020

The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor

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12 December 2020

Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1

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Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

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Immunohistochemistry of the Hfe protein in patients with hereditary hemochromatosis, iron deficiency anemia, and normal controls

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12 December 2020

Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis

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Mechanisms of iron accumulation in hereditary hemochromatosis

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Genes that modify the hemochromatosis phenotype in mice

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A novel mammalian iron-regulated protein involved in intracellular iron metabolism

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The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells

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12 December 2020

Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co‐inducibility during iron overload1

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12 December 2020

Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders.

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12 December 2020

Duodenal metal-transporter (DMT-1, NRAMP-2) expression in patients with hereditary haemochromatosis

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12 December 2020

Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein

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12 December 2020

Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload

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12 December 2020

Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation

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Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.

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12 December 2020

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

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12 December 2020

The C282Y mutation causing hereditary hemochromatosis does not produce a null allele

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12 December 2020

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

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12 December 2020

Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis.

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Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats

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Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells

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12 December 2020

Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis

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12 December 2020

Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1

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12 December 2020

A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation

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12 December 2020

A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

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12 December 2020

Expression of the two mRNA isoforms of the iron transporter Nramp2/DMTI in mice and function of the iron responsive element

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12 December 2020

Disorders of iron metabolism

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12 December 2020

C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism

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12 December 2020

Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis

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12 December 2020

Associations between cellular immune effector function, iron metabolism, and disease activity in patients with chronic hepatitis C virus infection

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12 December 2020

Decreased liver hepcidin expression in the Hfe knockout mouse

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12 December 2020

Inactivation of the hemochromatosis gene differentially regulates duodenal expression of iron-related mRNAs between mouse strains

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12 December 2020

Regulation of iron metabolism in eukaryotes

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Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis

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Cloning, sequencing and characterization of the rat hereditary hemochromatosis promoter: comparison of the human, mouse and rat HFE promoter regions.

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12 December 2020

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

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12 December 2020

Interactions of the ectodomain of HFE with the transferrin receptor are critical for iron homeostasis in cells

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12 December 2020

LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity

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Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis

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12 December 2020

HFE downregulates iron uptake from transferrin and induces iron-regulatory protein activity in stably transfected cells.

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12 December 2020

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress

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Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

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12 December 2020

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

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12 December 2020

Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease

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12 December 2020

Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease

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Duodenal expression of iron transport molecules in untreated haemochromatosis subjects.

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The hemochromatosis protein HFE inhibits iron export from macrophages.

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Experimental hemochromatosis due to MHC class I HFE deficiency: immune status and iron metabolism

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Hepcidin, a urinary antimicrobial peptide synthesized in the liver

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Iron-dependent regulation of the divalent metal ion transporter

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Cell surface expression of HFE protein in epithelial cells, macrophages, and monocytes

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Overexpression of the hereditary hemochromatosis protein, HFE, in HeLa cells induces an iron-deficient phenotype

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HFE gene knockout produces mouse model of hereditary hemochromatosis

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Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs

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12 December 2020

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

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12 December 2020

Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway

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12 December 2020

Intestinal iron uptake determined by divalent metal transporter is enhanced in HFE-deficient mice with hemochromatosis.

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12 December 2020

10.1007/S00109-004-0542-3

Identifiers

DOI

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15 January 2018

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15 January 2018