V(D)J Recombination Frequencies Can Be Profoundly Affected by Changes in the Spacer Sequence (Q47395217)

15 January 2018

title

V(D)J Recombination Frequencies Can Be Profoundly Affected by Changes in the Spacer Sequence (English)

1 reference

Crossref

DOI

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

B-lymphocyte gene rearrangement

30 March 2024

main subject

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14607931

T-lymphocyte gene rearrangement

30 March 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14607931

30 March 2024

genetic recombination

1 reference

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30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

30 March 2024

Alina Montalbano

1 reference

15 January 2018

Alan Tang

1 reference

15 January 2018

Mani Larijani

1 reference

15 January 2018

Kisani M. Ogwaro

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14607931

30 March 2024

Adam G. W. Matthews

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14607931

30 March 2024

Marjorie A. Oettinger

1 reference

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30 March 2024

Ann J. Feeney

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30 March 2024

language of work or name

English

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publication date

1 November 2003

1 reference

15 January 2018

15 November 2003

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14607931

30 March 2024

published in

Journal of Immunology

1 reference

15 January 2018

volume

171

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15 January 2018

issue

1 reference

15 January 2018

page(s)

5296-5304

1 reference

15 January 2018

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

cites work

1 reference

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Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

V(D)J recombination: a functional definition of the joining signals

30 March 2024

1 reference

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Two pairs of recombination signals are sufficient to cause immunoglobulin V-(D)-J joining

30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

Conservation of sequence in recombination signal sequence spacers

30 March 2024

1 reference

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Level of human TCRBV3S1 (V beta 3) expression correlates with allelic polymorphism in the spacer region of the recombination signal sequence

30 March 2024

1 reference

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Sequence of the spacer in the recombination signal sequence affects V(D)J rearrangement frequency and correlates with nonrandom Vkappa usage in vivo

30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

Mouse RSS spacer sequences affect the rate of V(D)J recombination

30 March 2024

1 reference

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The role of components of recombination signal sequences in immunoglobulin gene segment usage: a V81x model.

30 March 2024

1 reference

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Individual V(H) promoters vary in strength, but the frequency of rearrangement of those V(H) genes does not correlate with promoter strength nor enhancer-independence

30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

Unequal VH gene rearrangement frequency within the large VH7183 gene family is not due to recombination signal sequence variation, and mapping of the genes shows a bias of rearrangement based on chromosomal location

30 March 2024

1 reference

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DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences

30 March 2024

1 reference

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Assembly of the RAG1/RAG2 synaptic complex

30 March 2024

1 reference

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Functional analysis of coordinated cleavage in V(D)J recombination

30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes

30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

Molecular mechanisms and selective influences that shape the kappa gene repertoire of IgM+ B cells

30 March 2024

1 reference

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Coding end sequence can markedly affect the initiation of V(D)J recombination

30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

The composition of coding joints formed in V(D)J recombination is strongly affected by the nucleotide sequence of the coding ends and their relationship to the recombination signal sequences

30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

V(D)J recombination coding junction formation without DNA homology: processing of coding termini

30 March 2024

1 reference

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Identification and utilization of arbitrary correlations in models of recombination signal sequences

30 March 2024

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The cleavage efficiency of the human immunoglobulin heavy chain VH elements by the RAG complex: implications for the immune repertoire

30 March 2024

1 reference

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Genetic modulation of T cell receptor gene segment usage during somatic recombination

30 March 2024

1 reference

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Footprint analysis of the RAG protein recombination signal sequence complex for V(D)J type recombination.

30 March 2024

1 reference

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V(D)J recombination signal recognition: distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2.

30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

Enhancer control of V(D)J recombination at the TCRbeta locus: differential effects on DNA cleavage and joining

30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

Postcleavage sequence specificity in V(D)J recombination

30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination

30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

Joining-deficient RAG1 mutants block V(D)J recombination in vivo and hairpin opening in vitro

30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination

30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase

30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

Deletion of germline promoter PD beta 1 from the TCR beta locus causes hypermethylation that impairs D beta 1 recombination by multiple mechanisms.

30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.

30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells

30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

Cutting edge: targeting of V beta to D beta rearrangement by RSSs can be mediated by the V(D)J recombinase in the absence of additional lymphoid-specific factors

30 March 2024

1 reference

https://api.crossref.org/works/10.4049/JIMMUNOL.171.10.5296

30 March 2024

Identifiers

DOI

1 reference

15 January 2018

1 reference

15 January 2018