The cleavage efficiency of the human immunoglobulin heavy chain VH elements by the RAG complex: implications for the immune repertoire (Q43470902)

23 November 2017

title

The cleavage efficiency of the human immunoglobulin heavy chain VH elements by the RAG complex: implications for the immune repertoire (English)

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23 November 2017

Kefei Yu

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23 November 2017

Alex Taghva

series ordinal

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23 November 2017

Michael R Lieber

series ordinal

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23 November 2017

language of work or name

English

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publication date

5 December 2001

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Journal of Biological Chemistry

23 November 2017

published in

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23 November 2017

volume

277

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23 November 2017

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23 November 2017

page(s)

5040-5046

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The RAG proteins and V(D)J recombination: complexes, ends, and transposition

23 November 2017

cites work

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Warner-Lambert/Parke-Davis Award Lecture. Pathological and physiological double-strand breaks: roles in cancer, aging, and the immune system

21 January 2018

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The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses

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Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

21 January 2018

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Somatic generation of antibody diversity

21 January 2018

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The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination

21 January 2018

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Initiation of V(D)J recombination in vitro obeying the 12/23 rule

21 January 2018

1 reference

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The RAG-HMG1 complex enforces the 12/23 rule of V(D)J recombination specifically at the double-hairpin formation step

21 January 2018

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Antigen receptor gene rearrangement

21 January 2018

1 reference

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Two pairs of recombination signals are sufficient to cause immunoglobulin V-(D)-J joining

21 January 2018

1 reference

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Coding end sequence can markedly affect the initiation of V(D)J recombination

21 January 2018

1 reference

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Coding sequence composition flanking either signal element alters V(D)J recombination efficiency

21 January 2018

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Asymmetric processing of coding ends and the effect of coding end nucleotide composition on V(D)J recombination

21 January 2018

1 reference

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The composition of coding joints formed in V(D)J recombination is strongly affected by the nucleotide sequence of the coding ends and their relationship to the recombination signal sequences

21 January 2018

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Mouse kappa light-chain recombination signal sequences mediate recombination more frequently than do those of lambda light chain

21 January 2018

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Development of the primary antibody repertoire

21 January 2018

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Influence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate

21 January 2018

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Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1.

21 January 2018

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Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase

21 January 2018

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Stimulation of V(D)J recombination by histone acetylation

21 January 2018

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A role for histone acetylation in the developmental regulation of VDJ recombination.

21 January 2018

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Methylation patterns of immunoglobulin genes in lymphoid cells: correlation of expression and differentiation with undermethylation

21 January 2018

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Methylation status and DNase I sensitivity of immunoglobulin genes: changes associated with rearrangement

21 January 2018

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Comparison of the fetal and adult functional B cell repertoires by analysis of VH gene family expression

21 January 2018

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Unequal VH gene rearrangement frequency within the large VH7183 gene family is not due to recombination signal sequence variation, and mapping of the genes shows a bias of rearrangement based on chromosomal location

21 January 2018

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Germline diversity of the expressed BALB/c VhJ558 gene family

21 January 2018

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Early restriction of the human antibody repertoire

21 January 2018

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Development of the immunoglobulin repertoire

21 January 2018

1 reference

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Structure and evolution of mammalian VH families

21 January 2018

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V(D)J Recombination: In Vitro Coding Joint Formation

21 January 2018

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The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus

21 January 2018

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Initiation of V(D)J recombination in a cell-free system.

21 January 2018

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Mechanistic basis for coding end sequence effects in the initiation of V(D)J recombination

21 January 2018

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Functional analysis of coordinated cleavage in V(D)J recombination

21 January 2018

1 reference

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The nicking step in V(D)J recombination is independent of synapsis: implications for the immune repertoire

21 January 2018

1 reference

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Nicking is asynchronous and stimulated by synapsis in 12/23 rule-regulated V(D)J cleavage

21 January 2018

1 reference

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Conservation of sequence in recombination signal sequence spacers

21 January 2018

1 reference

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Sequence of the spacer in the recombination signal sequence affects V(D)J rearrangement frequency and correlates with nonrandom Vkappa usage in vivo

21 January 2018

1 reference

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Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells

21 January 2018

1 reference

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Use of immunoglobulin variable-region genes by normal subjects and patients with systemic lupus erythematosus

21 January 2018

1 reference

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Regulation of the antibody repertoire through control of HCDR3 diversity.

21 January 2018

1 reference

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Evolution of the recombination signal sequences in the Ig heavy-chain variable region locus of mammals

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M109772200

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23 November 2017

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