Drosophila Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase (Q47072454)

5 January 2018

title

Drosophila Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase (English)

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5 January 2018

Regulator of cullins 2 Dmel_CG8998

main subject

Drosophila

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1 reference

Regulator of cullins 1b Dmel_CG16988

GOA release 2020-03-11

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Regulator of cullins 1a Dmel_CG16982

GOA release 2020-03-11

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GOA release 2020-03-11

author name string

Maher A Noureddine

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5 January 2018

Timothy D Donaldson

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5 January 2018

Stephen A Thacker

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5 January 2018

Robert J Duronio

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5 January 2018

language of work or name

English

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publication date

1 June 2002

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5 January 2018

number of pages

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inferred from page(s)

published in

Developmental Cell

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5 January 2018

volume

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5 January 2018

issue

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5 January 2018

page(s)

757-770

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5 January 2018

Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity

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Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

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Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4.

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In vivo and in vitro characterization of the B1 and B2 zinc-binding domains from the acute promyelocytic leukemia protooncoprotein PML

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The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development.

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

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Constructing deletions with defined endpoints in Drosophila

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The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

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A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p

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The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence

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RING for destruction?

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7 January 2021

Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins

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7 January 2021

The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1

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7 January 2021

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

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The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex

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The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

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7 January 2021

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

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7 January 2021

Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing

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7 January 2021

Regulation of transcription by ubiquitination without proteolysis: Cdc34/SCF(Met30)-mediated inactivation of the transcription factor Met4.

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7 January 2021

Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1.

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The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2

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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

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7 January 2021

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

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7 January 2021

Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis

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7 January 2021

Genetic dissection of the Drosophila Cubitus interruptus signaling complex

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7 January 2021

The APC11 RING-H2 finger mediates E2-dependent ubiquitination

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7 January 2021

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

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7 January 2021

Identification and preliminary characterization of a protein motif related to the zinc finger

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7 January 2021

Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation

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7 January 2021

Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.

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7 January 2021

Drosophila null slimb clones transiently deregulate Hedgehog-independent transcription of wingless in all limb discs, and induce decapentaplegic transcription linked to imaginal disc regeneration

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7 January 2021

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

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The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways

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7 January 2021

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

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7 January 2021

Coordination of growth and cell division in the Drosophila wing

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7 January 2021

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator

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7 January 2021

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

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7 January 2021

SCF(Met30)-mediated control of the transcriptional activator Met4 is required for the G(1)-S transition

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7 January 2021

Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast

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7 January 2021

Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus

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7 January 2021

The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin.

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7 January 2021

Gli proteins and Hedgehog signaling: development and cancer

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7 January 2021

Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex

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7 January 2021

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

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7 January 2021

Control of Swe1p degradation by the morphogenesis checkpoint

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7 January 2021

F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

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7 January 2021

Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

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7 January 2021

Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

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7 January 2021

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

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7 January 2021

WormBase: network access to the genome and biology of Caenorhabditis elegans

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7 January 2021

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

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7 January 2021

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

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7 January 2021

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

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7 January 2021

Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

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7 January 2021

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

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7 January 2021

SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities

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7 January 2021

Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus

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7 January 2021

The SCF ubiquitin ligase protein slimb regulates centrosome duplication in Drosophila.

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7 January 2021

Identification of a Cullin Homology Region in a Subunit of the Anaphase-Promoting Complex

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7 January 2021

Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins.

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7 January 2021

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

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7 January 2021

10.1016/S1534-5807(02)00164-8

Identifiers

DOI

1 reference

5 January 2018

1 reference

5 January 2018