An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons (Q46916073)

26 December 2017

title

An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons (English)

1 reference

26 December 2017

Steven P Gygi

1 reference

26 December 2017

author name string

Monica Boselli

1 reference

26 December 2017

Byung-Hoon Lee

1 reference

26 December 2017

Jessica Robert

1 reference

26 December 2017

Miguel A Prado

1 reference

26 December 2017

Sang-Won Min

1 reference

26 December 2017

Chialin Cheng

1 reference

26 December 2017

M Catarina Silva

1 reference

26 December 2017

Changhyun Seong

1 reference

26 December 2017

Suzanne Elsasser

1 reference

26 December 2017

Ketki M Hatle

1 reference

26 December 2017

Timothy C Gahman

1 reference

26 December 2017

Stephen J Haggarty

1 reference

26 December 2017

Li Gan

1 reference

26 December 2017

Randall W King

1 reference

26 December 2017

Daniel Finley

1 reference

26 December 2017

language of work or name

English

0 references

publication date

26 September 2017

1 reference

26 December 2017

Journal of Biological Chemistry

published in

1 reference

26 December 2017

volume

292

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26 December 2017

issue

1 reference

26 December 2017

page(s)

19209-19225

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26 December 2017

Proteasome Structure and Assembly

cites work

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The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis

26 August 2018

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26 August 2018

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A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction

26 August 2018

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USP7 deubiquitinase controls HIV-1 production by stabilizing Tat protein

26 August 2018

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Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptor

26 August 2018

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USP14 inhibitor attenuates cerebral ischemia/reperfusion-induced neuronal injury in mice

26 August 2018

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TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses.

26 August 2018

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Role of the deubiquitinating enzyme ubiquitin-specific protease-14 in proteostasis in renal cells.

26 August 2018

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Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability

26 August 2018

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USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1

26 August 2018

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UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome

26 August 2018

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USP14 de-ubiquitinates vimentin and miR-320a modulates USP14 and vimentin to contribute to malignancy in gastric cancer cells

26 August 2018

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Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model

26 August 2018

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USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Inhibition of deubiquitinating activity of USP14 decreases tyrosine hydroxylase phosphorylated at Ser19 in PC12D cells

26 August 2018

1 reference

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Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins.

26 August 2018

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Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome system

26 August 2018

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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Ubiquitin-specific protease 14 modulates degradation of cellular prion protein

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Media formulation influences chemical effects on neuronal growth and morphology.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Autophagy in neuronal cells: general principles and physiological and pathological functions

26 August 2018

1 reference

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Sculpting the proteome with small molecules

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Distinct tau prion strains propagate in cells and mice and define different tauopathies

26 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Proteases in cardiometabolic diseases: Pathophysiology, molecular mechanisms and clinical applications

26 August 2018

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Paradigms of protein degradation by the proteasome

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Emerging therapies targeting the ubiquitin proteasome system in cancer

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Genetic background alters the severity and onset of neuromuscular disease caused by the loss of ubiquitin-specific protease 14 (usp14)

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short-term plasticity and vesicle number.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Deubiquitylases from genes to organism

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Acetylated tau neuropathology in sporadic and hereditary tauopathies

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Regulation of proteolysis by human deubiquitinating enzymes

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

26 August 2018

What Renders TAU Toxic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

MicroRNA-124 protects against focal cerebral ischemia via mechanisms involving Usp14-dependent REST degradation.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Ubiquitinated proteins activate the proteasomal ATPases by binding to Usp14 or Uch37 homologs

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Compensatory increase in USP14 activity accompanies impaired proteasomal proteolysis during aging

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Deubiquitinating enzymes as therapeutic targets in cancer

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Design principles of a universal protein degradation machine

26 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

A high-throughput screen for Wnt/β-catenin signaling pathway modulators in human iPSC-derived neural progenitors

26 August 2018

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Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

26 August 2018

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Regulation and physiological roles of the calpain system in muscular disorders

26 August 2018

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26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits Dengue virus replication

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Neuronal autophagy and neurodegenerative diseases

26 August 2018

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26 August 2018

The many faces of tau

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Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies

26 August 2018

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Acetylation of tau inhibits its degradation and contributes to tauopathy

26 August 2018

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Enhancement of proteasome activity by a small-molecule inhibitor of USP14

26 August 2018

1 reference

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

26 August 2018

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26 August 2018

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Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice

26 August 2018

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Recognition and processing of ubiquitin-protein conjugates by the proteasome

26 August 2018

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The role of tau in neurodegeneration

26 August 2018

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Analyzing real-time PCR data by the comparative C(T) method

26 August 2018

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A ubiquitin stress response induces altered proteasome composition.

26 August 2018

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Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy

26 August 2018

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Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14

26 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Failure of protein quality control in amyotrophic lateral sclerosis

26 August 2018

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Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Tau suppression in a neurodegenerative mouse model improves memory function

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

The role of tau (MAPT) in frontotemporal dementia and related tauopathies

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

26 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

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26 August 2018

1 reference

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Multiple associated proteins regulate proteasome structure and function

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Staurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanisms

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Tau pathology in a family with dementia and a P301L mutation in tau.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5702663

Calpain‐Induced Proteolysis of Normal Human Tau and Tau Associated with Paired Helical Filaments

26 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28972160

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

FTDP-17: an early-onset phenotype with parkinsonism and epileptic seizures caused by a novel mutation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28972160

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Preparation of ubiquitinated substrates by the PY motif-insertion method for monitoring 26S proteasome activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28972160

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M117.815126

1 reference

26 December 2017

PMC publication ID

5702663

0 references

1 reference

26 December 2017