Transgenic expression of the deoxynucleotide carrier causes mitochondrial damage that is enhanced by NRTIs for AIDS. (Q46542423)

23 December 2017

title

Transgenic expression of the deoxynucleotide carrier causes mitochondrial damage that is enhanced by NRTIs for AIDS. (English)

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23 December 2017

author name string

William Lewis

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23 December 2017

Chad P Haase

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23 December 2017

Yoon K Miller

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23 December 2017

Brandy Ferguson

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23 December 2017

Tami Stuart

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23 December 2017

Tomika Ludaway

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23 December 2017

Jamie McNaught

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23 December 2017

Rodney Russ

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23 December 2017

Jeffrey Steltzer

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23 December 2017

Robert Santoianni

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23 December 2017

Robert Long

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23 December 2017

Giuseppe Fiermonte

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23 December 2017

Ferdinando Palmieri

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23 December 2017

publication date

1 August 2005

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23 December 2017

published in

Laboratory Investigation

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23 December 2017

volume

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23 December 2017

issue

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23 December 2017

page(s)

972-981

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23 December 2017

The mitochondrial transporter family (SLC25): physiological and pathological implications

cites work

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

The human mitochondrial deoxynucleotide carrier and its role in the toxicity of nucleoside antivirals

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Mitochondrial carrier proteins

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Mitochondrial toxicity of nrti antiviral drugs: an integrated cellular perspective

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Targeted myocardial transgenic expression of HIV Tat causes cardiomyopathy and mitochondrial damage.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Cardiac dysfunction occurs in the HIV-1 transgenic mouse treated with zidovudine

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Mitochondrial myopathy caused by long-term zidovudine therapy

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Cocaine increases mortality and cardiac mass in a murine transgenic model of acquired immune deficiency syndrome

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Electrocardiographic findings in mdx mice: a cardiac phenotype of Duchenne muscular dystrophy

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Method for non-invasively recording electrocardiograms in conscious mice

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Phenotypic screening for heart rate variability in the mouse

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Crystal structures of the mitochondrial deoxyribonucleotidase in complex with two specific inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Mitochondrial deoxyribonucleotides, pool sizes, synthesis, and regulation

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Cytosolic and mitochondrial deoxyribonucleotidases: activity with substrate analogs, inhibitors and implications for therapy

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

A deoxyribonucleotidase in mitochondria: involvement in regulation of dNTP pools and possible link to genetic disease

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Kinetic properties of mutant human thymidine kinase 2 suggest a mechanism for mitochondrial DNA depletion myopathy

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Mitochondrial deoxyribonucleoside triphosphate pools in thymidine kinase 2 deficiency

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

mtDNA depletion myopathy: elucidation of the tissue specificity in the mitochondrial thymidine kinase (TK2) deficiency

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Mice deficient for cytosolic thymidine kinase gene develop fatal kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Expression of human mitochondrial thymidine kinase in Escherichia coli: correlation between the enzymatic activity of pyrimidine nucleoside analogues and their inhibitory effect on bacterial growth

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Toxicity of nucleoside analogues used to treat AIDS and the selectivity of the mitochondrial DNA polymerase

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondri

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Insights into the molecular mechanism of mitochondrial toxicity by AIDS drugs

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Nucleotide incorporation by human DNA polymerase gamma opposite benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyguanosine and deoxyadenosine.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

DNA polymerase gamma, the mitochondrial replicase

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Mitochondrial toxicity of antiviral drugs

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Mitochondrial dna depletion, oxidative stress, and mutation: mechanisms of dysfunction from nucleoside reverse transcriptase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

A novel HIV-1 transgenic rat model of childhood HIV-1-associated nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

An HIV-1 transgenic rat that develops HIV-related pathology and immunologic dysfunction

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Nef modulation of HIV type 1 gene expression and cytopathicity in tissues of HIV transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Transgenic mouse model of ethanol as a cofactor in HIV disease

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Transgenic dissection of HIV genes involved in lymphoid depletion

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Is the failing heart energy depleted?

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Echocardiography in HIV cardiac disease

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Defective mitochondrial DNA replication and NRTIs: pathophysiological implications in AIDS cardiomyopathy

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Mitochondrial toxicity in fetal Erythrocebus patas monkeys exposed transplacentally to zidovudine plus lamivudine

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

Mitochondrial damage and DNA depletion in cord blood and umbilical cord from infants exposed in utero to Combivir

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700301

7 January 2021

10.1038/LABINVEST.3700301

Identifiers

DOI

1 reference

23 December 2017

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23 December 2017