Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing (Q46240526)

20 December 2017

title

Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing (English)

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20 December 2017

main subject

etazolate

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ChEBI release 2020-05-28

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Maryline Marcade

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20 December 2017

Jérôme Bourdin

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20 December 2017

Nadia Loiseau

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20 December 2017

Hélène Peillon

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20 December 2017

Aurélie Rayer

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20 December 2017

Dominique Drouin

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20 December 2017

Fabien Schweighoffer

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20 December 2017

Laurent Désiré

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20 December 2017

language of work or name

English

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publication date

1 July 2008

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20 December 2017

Journal of Neurochemistry

published in

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20 December 2017

volume

106

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20 December 2017

issue

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20 December 2017

page(s)

392-404

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20 December 2017

BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors

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Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone.

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Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.

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An inverse agonist selective for alpha5 subunit-containing GABAA receptors enhances cognition.

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RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo.

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Increase in extracellular NCAM and amyloid precursor protein following induction of long-term potentiation in the dentate gyrus of anaesthetized rats

21 January 2018

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Activation of muscarinic receptors inhibits beta-amyloid peptide-induced signaling in cortical slices

21 January 2018

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Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death.

21 January 2018

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Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence

21 January 2018

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Furin is an endogenous regulator of alpha-secretase associated APP processing

21 January 2018

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Acceleration of amyloid beta-peptide aggregation by physiological concentrations of calcium

21 January 2018

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21 January 2018

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21 January 2018

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Chronic stimulation of GABAA receptor with muscimol reduces amyloid beta protein (25-35)-induced neurotoxicity in cultured rat cortical cells

21 January 2018

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Neuroprotection by D-securinine against neurotoxicity induced by beta-amyloid (25-35).

21 January 2018

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Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders

21 January 2018

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Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha

21 January 2018

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Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity

21 January 2018

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Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

21 January 2018

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21 January 2018

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21 January 2018

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Functional modulation of GABAA receptors by cAMP-dependent protein phosphorylation

21 January 2018

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Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain

21 January 2018

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Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

21 January 2018

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Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices

21 January 2018

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Regulation of APP cleavage by alpha-, beta- and gamma-secretases

21 January 2018

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21 January 2018

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21 January 2018

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The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

21 January 2018

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Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.

21 January 2018

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A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis

21 January 2018

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GABA receptors ameliorate Hcy-mediated integrin shedding and constrictive collagen remodeling in microvascular endothelial cells

21 January 2018

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Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons.

21 January 2018

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Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis.

21 January 2018

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Tracazolate reveals a novel type of allosteric interaction with recombinant gamma-aminobutyric acid(A) receptors

21 January 2018

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Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

21 January 2018

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Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

21 January 2018

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Expression, purification, and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D.

21 January 2018

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A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2008.05396.X

10.1111/J.1471-4159.2008.05396.X

21 January 2018

Identifiers

DOI

1 reference

20 December 2017

1 reference

20 December 2017