Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015). (Q45180301)

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31 October 2019

title

Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015) (English)

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31 October 2019

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31 October 2019

S J Ries

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31 October 2019

A S Chung

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31 October 2019

C H Biederer

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31 October 2019

B C Hann

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31 October 2019

E M Lipner

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31 October 2019

F McCormick

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31 October 2019

W M Korn

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31 October 2019

language of work or name

English

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publication date

1 October 2000

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31 October 2019

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31 October 2019

volume

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31 October 2019

issue

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31 October 2019

page(s)

1128-1133

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Clonal analysis of human colorectal tumors

31 October 2019

cites work

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Implications of the p53 tumor-suppressor gene in clinical oncology.

21 January 2018

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Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

21 January 2018

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a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

21 January 2018

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ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

21 January 2018

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An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

21 January 2018

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Mdm2: keeping p53 under control

21 January 2018

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

21 January 2018

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

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p14ARF links the tumour suppressors RB and p53.

21 January 2018

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E1A signaling to p53 involves the p19(ARF) tumor suppressor

21 January 2018

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Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

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Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

21 January 2018

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Increased accumulation of p53 protein in cisplatin-resistant ovarian cell lines

21 January 2018

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Infectivity and expression of the early adenovirus proteins are important regulators of wild-type and DeltaE1B adenovirus replication in human cells

21 January 2018

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Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

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Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor

21 January 2018

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P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

21 January 2018

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INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

21 January 2018

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p53-dependent cell death/apoptosis is required for a productive adenovirus infection

21 January 2018

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Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport

21 January 2018

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p53 status and the efficacy of cancer therapy in vivo

21 January 2018

1 reference

7 January 2021

Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy

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7 January 2021

p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection

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7 January 2021

mdm2 expression is induced by wild type p53 activity

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7 January 2021

Identifiers

DOI

10.1038/80466

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Dimensions Publication ID

31 October 2019

1046045283

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1 reference

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