Identification of intermediates in the bile acid synthetic pathway as ligands for the farnesoid X receptor (Q44897916)

7 December 2017

title

Identification of intermediates in the bile acid synthetic pathway as ligands for the farnesoid X receptor (English)

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7 December 2017

author name string

Tomoko Nishimaki-Mogami

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7 December 2017

Mizuho Une

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7 December 2017

Tomofumi Fujino

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7 December 2017

Yoji Sato

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7 December 2017

Norimasa Tamehiro

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7 December 2017

Yosuke Kawahara

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7 December 2017

Koichi Shudo

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7 December 2017

Kazuhide Inoue

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7 December 2017

language of work or name

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16 May 2004

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Journal of Lipid Research

7 December 2017

published in

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7 December 2017

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7 December 2017

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7 December 2017

page(s)

1538-1545

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7 December 2017

cites work

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Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

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Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

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27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells

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Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity

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Identification of CYP3A4 as the major enzyme responsible for 25-hydroxylation of 5beta-cholestane-3alpha,7alpha,12alpha-triol in human liver microsomes

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The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion

21 January 2018

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Bile acid profiles in peroxisomal 3-oxoacyl-coenzyme A thiolase deficiency

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Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

21 January 2018

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Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis

21 January 2018

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21 January 2018

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Side chain hydroxylations in bile acid biosynthesis catalyzed by CYP3A are markedly up-regulated in Cyp27-/- mice but not in cerebrotendinous xanthomatosis.

21 January 2018

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Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene

21 January 2018

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21 January 2018

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Structural basis for bile acid binding and activation of the nuclear receptor FXR

21 January 2018

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Structure-activity relationship of bile acids and bile acid analogs in regard to FXR activation

21 January 2018

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FOR, a novel orphan nuclear receptor related to farnesoid X receptor

21 January 2018

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10.1194/JLR.M400102-JLR200

21 January 2018

Identifiers

DOI

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7 December 2017

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