Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator (Q33976397)

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English	Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

30 July 2017

Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Paul A. Lapchak

1

object named as

Paul A Lapchak

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

author name string

Moon Ku Han

2

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Europe PubMed Central

PubMed publication ID

30 July 2017

language of work or name

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publication date

19 May 2010

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Europe PubMed Central

PubMed publication ID

30 July 2017

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Europe PubMed Central

PubMed publication ID

30 July 2017

1344

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Europe PubMed Central

PubMed publication ID

30 July 2017

217-225

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Translational stroke research using a rabbit embolic stroke model: a correlative analysis hypothesis for novel therapy development

1 reference

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From here to JUPITER: identifying new patients for statin therapy using data from the 1999-2004 National Health and Nutrition Examination Survey

1 reference

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Efficacy and safety profile of the carotenoid trans sodium crocetinate administered to rabbits following multiple infarct ischemic strokes: a combination therapy study with tissue plasminogen activator

1 reference

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Transcranial near infrared laser treatment (NILT) increases cortical adenosine-5'-triphosphate (ATP) content following embolic strokes in rabbits

1 reference

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Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling.

1 reference

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Simvastatin and atorvastatin improve neurological outcome after experimental intracerebral hemorrhage

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Atorvastatin extends the therapeutic window for tPA to 6 h after the onset of embolic stroke in rats

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High-dose lovastatin for acute ischemic stroke: results of the phase I dose escalation neuroprotection with statin therapy for acute recovery trial (NeuSTART)

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Efficacy and safety of tissue plasminogen activator 3 to 4.5 hours after acute ischemic stroke: a metaanalysis.

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Statins: mechanisms of neuroprotection

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Effects of NXY-059 in experimental stroke: an individual animal meta-analysis

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The Neuroprotection with Statin Therapy for Acute Recovery Trial (NeuSTART): an adaptive design phase I dose-escalation study of high-dose lovastatin in acute ischemic stroke

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Simvastatin attenuation of cerebral vasospasm after subarachnoid hemorrhage in rats via increased phosphorylation of Akt and endothelial nitric oxide synthase

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Simvastatin: two decades in a circle

1 reference

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Applications for ROCK kinase inhibition

1 reference

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The PI3K/Akt pathway mediates the neuroprotective effect of atorvastatin in extending thrombolytic therapy after embolic stroke in the rat.

1 reference

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Prior statin use reduces mortality in intracerebral hemorrhage

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Advances in ischemic stroke treatment: neuroprotective and combination therapies

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Vascular endothelial growth factor mediates atorvastatin-induced mammalian achaete-scute homologue-1 gene expression and neuronal differentiation after stroke in retired breeder rats

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Statin-mediated protective effects in the central nervous system: general mechanisms and putative role of stress proteins.

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The role of statins in clinical medicine--LDL--cholesterol lowering and beyond

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Statin safety: an overview and assessment of the data--2005.

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Lipids and stroke: the opportunity of lipid-lowering treatment

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Multitargeted effects of statin-enhanced thrombolytic therapy for stroke with recombinant human tissue-type plasminogen activator in the rat.

1 reference

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Atorvastatin downregulates tissue plasminogen activator-aggravated genes mediating coagulation and vascular permeability in single cerebral endothelial cells captured by laser microdissection

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Neuroprotective effect of simvastatin in stroke: a comparison between adult and neonatal rat models of cerebral ischemia.

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Rho kinase, a promising drug target for neurological disorders

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HMG CoA reductase inhibitors (statins): use in stroke prevention and outcome after stroke

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Treatment with statins in the acute phase of ischemic stroke.

1 reference

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Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice

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HMG-CoA reductase inhibitor, atorvastatin, promotes sensorimotor recovery, suppressing acute inflammatory reaction after experimental intracerebral hemorrhage

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Statin inhibition of HMG-CoA reductase: a 3-dimensional view

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Development of thrombolytic therapy for stroke: a perspective

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Statins and ischemic stroke

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Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice

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Pleiotropic effects of HMG-CoA reductase inhibitors

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Underlying structure of the National Institutes of Health Stroke Scale: results of a factor analysis. NINDS tPA Stroke Trial Investigators

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Vascular Effects of Statins in Stroke

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Treatment with statins after induction of focal ischemia in rats reduces the extent of brain damage

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High-dose atorvastatin after stroke or transient ischemic attack

1 reference

https://pubmed.ncbi.nlm.nih.gov/20493175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of tissue plasminogen activator-induced matrix metalloproteinase-9 by simvastatin in astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20493175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statins and stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/20493175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The rtPA (alteplase) 0- to 6-hour acute stroke trial, part A (A0276g) : results of a double-blind, placebo-controlled, multicenter study. Thromblytic therapy in acute ischemic stroke study investigators

1 reference

https://pubmed.ncbi.nlm.nih.gov/20493175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels study

1 reference

https://pubmed.ncbi.nlm.nih.gov/20493175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statin use was not associated with less vasospasm or improved outcome after subarachnoid hemorrhage

1 reference

https://pubmed.ncbi.nlm.nih.gov/20493175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BRAINRES.2010.05.035

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

ResearchGate publication ID

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