Rho kinase, a promising drug target for neurological disorders (Q36111908)

12 August 2017

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title

Rho kinase, a promising drug target for neurological disorders (English)

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12 August 2017

Nicole Teusch

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Bernhard K Mueller

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12 August 2017

Helmut Mack

series ordinal

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12 August 2017

publication date

1 May 2005

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Nature Reviews Drug Discovery

12 August 2017

published in

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12 August 2017

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12 August 2017

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12 August 2017

page(s)

387-398

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Rho and Rac take center stage

12 August 2017

cites work

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Rho GTPases and their effector proteins

21 January 2018

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GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

21 January 2018

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ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice

21 January 2018

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Regulation and functions of Rho-associated kinase

21 January 2018

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Distribution of Rho-kinase in the bovine brain

21 January 2018

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The COOH terminus of Rho-kinase negatively regulates rho-kinase activity.

21 January 2018

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Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha

21 January 2018

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Myotonic dystrophy protein kinase domains mediate localization, oligomerization, novel catalytic activity, and autoinhibition

21 January 2018

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Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase

21 January 2018

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Structural insights into the interaction of ROCKI with the switch regions of RhoA

21 January 2018

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Characterization and purification of truncated human Rho-kinase II expressed in Sf-21 cells

21 January 2018

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The effects of the Rho-kinase inhibitor Y-27632 on arachidonic acid-, GTPgammaS-, and phorbol ester-induced Ca2+-sensitization of smooth muscle

21 January 2018

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Sphingosylphosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+ sensitization in the bovine cerebral artery: unimportant role for protein kinase C

21 January 2018

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Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

21 January 2018

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Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I.

21 January 2018

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The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

21 January 2018

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Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II.

21 January 2018

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Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase

21 January 2018

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Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop

21 January 2018

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Phosphorylation of glial fibrillary acidic protein at the same sites by cleavage furrow kinase and Rho-associated kinase.

21 January 2018

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Domain- and site-specific phosphorylation of bovine NF-L by Rho-associated kinase

21 January 2018

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Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphatase.

21 January 2018

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Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse

21 January 2018

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ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles

21 January 2018

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Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death

21 January 2018

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Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study

21 January 2018

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Rho/Rho-kinase mediated signaling in physiology and pathophysiology

21 January 2018

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Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase

21 January 2018

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Rho GTPases: potential candidates for anticancer therapy

21 January 2018

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New directions for erectile dysfunction therapies

21 January 2018

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Basic advances and new avenues in therapy of spinal cord injury

21 January 2018

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21 January 2018

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Nogo and axon regeneration

21 January 2018

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Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration

21 January 2018

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Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth

21 January 2018

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Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor

21 January 2018

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Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth

21 January 2018

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The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein

21 January 2018

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P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp

21 January 2018

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A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein

21 January 2018

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LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

21 January 2018

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A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors

21 January 2018

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TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration

21 January 2018

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The Nogo signaling pathway for regeneration block

21 January 2018

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Role of EphA4 and EphrinB3 in local neuronal circuits that control walking

21 January 2018

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The Rho/ROCK pathway mediates neurite growth-inhibitory activity associated with the chondroitin sulfate proteoglycans of the CNS glial scar

21 January 2018

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Suppression of Rho-kinase activity promotes axonal growth on inhibitory CNS substrates

21 January 2018

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Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology

21 January 2018

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EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin

21 January 2018

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Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase

21 January 2018

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Spatial and temporal gene expression profiling of the contused rat spinal cord.

21 January 2018

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Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system

21 January 2018

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Activation of Rho in the injured axons following spinal cord injury

21 January 2018

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A possible role of RhoA/Rho-kinase in experimental spinal cord injury in rat.

21 January 2018

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Cytoplasmic p21(Cip1/WAF1) enhances axonal regeneration and functional recovery after spinal cord injury in rats.

21 January 2018

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Strategies for disease modification in Alzheimer's disease

21 January 2018

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Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

21 January 2018

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Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies

21 January 2018

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Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists: the Cache County study

21 January 2018

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

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Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

21 January 2018

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Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK

21 January 2018

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Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis.

21 January 2018

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Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis

21 January 2018

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Rho kinase regulates schwann cell myelination and formation of associated axonal domains.

21 January 2018

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Axonal transection in the lesions of multiple sclerosis

21 January 2018

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A new model of cerebral microthrombosis in rats and the neuroprotective effect of a Rho-kinase inhibitor

21 January 2018

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Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage

21 January 2018

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Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina

21 January 2018

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Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity.

21 January 2018

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Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling

21 January 2018

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Rho-kinase inhibition enhances axonal plasticity and attenuates cold hyperalgesia after dorsal rhizotomy.

21 January 2018

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Involvement of Rho-kinase in inflammatory and neuropathic pain through phosphorylation of myristoylated alanine-rich C-kinase substrate (MARCKS).

21 January 2018

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Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

21 January 2018

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Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases

21 January 2018

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Synthesis and evaluation of 4-(1-aminoalkyl)-N-(4-pyridyl)cyclohexanecarboxamides as Rho kinase inhibitors and neurite outgrowth promoters.

21 January 2018

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

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The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway

21 January 2018

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Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor.

21 January 2018

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Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity

21 January 2018

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Encapsulation of an antivasospastic drug, fasudil, into liposomes, and in vitro stability of the fasudil-loaded liposomes

21 January 2018

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Rho GTPases and signaling networks

21 January 2018

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Rho GTPases and their effector proteins

31 March 2020

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Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho

31 March 2020

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A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes

31 March 2020

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Rocks: multifunctional kinases in cell behaviour

31 March 2020

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New insights into the structure-function relationships of Rho-associated kinase: a thermodynamic and hydrodynamic study of the dimer-to-monomer transition and its kinetic implications

31 March 2020

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Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

31 March 2020

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Phosphorylation of vimentin by Rho-associated kinase at a unique amino-terminal site that is specifically phosphorylated during cytokinesis

31 March 2020

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Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebo-controlled double-blind trial

31 March 2020

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The tone of pulmonary smooth muscle: ROK and Rho music?

31 March 2020

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Signaling: focus on Rho in renal disease

31 March 2020

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A clinician's view of spinal cord injury

31 March 2020

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Acute spinal cord injury, part I: pathophysiologic mechanisms

31 March 2020

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Versican V2 and the central inhibitory domain of Nogo-A inhibit neurite growth via p75NTR/NgR-independent pathways that converge at RhoA.

31 March 2020

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Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Rac1

31 March 2020

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The transmembrane semaphorin Sema4D/CD100, an inhibitor of axonal growth, is expressed on oligodendrocytes and upregulated after CNS lesion

31 March 2020

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Upregulation of EphA receptor expression in the injured adult rat spinal cord.

31 March 2020

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Induction of Eph B3 after spinal cord injury

31 March 2020

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Lesional expression of RhoA and RhoB following traumatic brain injury in humans

31 March 2020

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Rho signaling pathway targeted to promote spinal cord repair.

31 March 2020

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Rho kinase inhibition enhances axonal regeneration in the injured CNS.

31 March 2020

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NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

31 March 2020

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Are statins a treatment option for multiple sclerosis?

31 March 2020

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Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis

31 March 2020

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RhoA activation promotes transendothelial migration of monocytes via ROCK.

31 March 2020

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Pathogenesis of brain and spinal cord atrophy in multiple sclerosis

31 March 2020

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Therapeutic potential of rho-kinase inhibitors in cardiovascular diseases

31 March 2020

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Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction

31 March 2020

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Use and properties of ROCK-specific inhibitor Y-27632.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD1719

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Dimensions Publication ID

12 August 2017

1044036815

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