A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy? (Q33938450)

30 July 2017

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title

A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy? (English)

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30 July 2017

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Paul A Lapchak

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language of work or name

English

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publication date

1 July 2010

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Expert Opinion on Pharmacotherapy

30 July 2017

published in

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

1753-1763

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CeeTox™ Analysis of CNB-001 a Novel Curcumin-Based Neurotrophic/Neuroprotective Lead Compound to Treat Stroke: Comparison with NXY-059 and Radicut

30 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Translational stroke research using a rabbit embolic stroke model: a correlative analysis hypothesis for novel therapy development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Effects of NXY-059 in experimental stroke: an individual animal meta-analysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Clinical analysis of 207 patients who developed renal disorders during or after treatment with edaravone reported during post-marketing surveillance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Neuroprotective effects of free radical scavengers in stroke

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

A case report of acute renal failure and fulminant hepatitis associated with edaravone administration in a cerebral infarction patient

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Advances in ischemic stroke treatment: neuroprotective and combination therapies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Potential markers of oxidative stress in stroke.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Attenuation of extravasation of tissue plasminogen activator by the free radical scavenger, edaravone: evaluation in a rat thromboembolic stroke model

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Stroke--incidence, mortality, morbidity and risk.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Development of the Nitrone‐Based Spin Trap Agent NXY‐059 to Treat Acute Ischemic Stroke

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Development of thrombolytic therapy for stroke: a perspective

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Treatment of acute ischemic stroke: recent progress

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Thrombolytic therapy for ischemic stroke--a review. Part II--Intra-arterial thrombolysis, vertebrobasilar stroke, phase IV trials, and stroke imaging

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Thrombolytic therapy for ischemic stroke--a review. Part I--Intravenous thrombolysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Finding the most powerful measures of the effectiveness of tissue plasminogen activator in the NINDS tPA stroke trial

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Antioxidants, oxidative stress, and degenerative neurological disorders

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Recommendations for standards regarding preclinical neuroprotective and restorative drug development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Newer thrombolytic agents

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Underlying structure of the National Institutes of Health Stroke Scale: results of a factor analysis. NINDS tPA Stroke Trial Investigators

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Pathobiology of ischaemic stroke: an integrated view

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Free radicals as mediators of neuronal injury

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

'Malignant' middle cerebral artery territory infarction: clinical course and prognostic signs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Mechanisms of secondary brain injury

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Mechanisms of secondary brain damage in global and focal ischemia: a speculative synthesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Improved reliability of the NIH Stroke Scale using video training. NINDS TPA Stroke Study Group

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Tissue plasminogen activator for acute ischemic stroke

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Tissue plasminogen activator reduces neurological damage after cerebral embolism.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Selective embolization and clot dissolution with tPA in the internal carotid artery circulation of the rabbit

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

The safety and angiographic efficacy of tissue plasminogen activator in a cerebral embolization model

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Effect of MCI-186 on ischemia-induced changes in monoamine metabolism in rat brain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Effect of MCI-186 on brain edema in rats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Evaluation of recombinant tissue plasminogen activator in embolic stroke

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Ischemic stroke subtypes: a population-based study of incidence and risk factors

5 July 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Stroke treatment with alteplase given 3.0-4.5 h after onset of acute ischaemic stroke (ECASS III): additional outcomes and subgroup analysis of a randomised controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

The novel antioxidant edaravone: from bench to bedside

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

The radical scavenger edaravone prevents oxidative neurotoxicity induced by peroxynitrite and activated microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Neuroprotective effects of the free radical scavenger Edaravone (MCI-186) in mice permanent focal brain ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Edaravone (3-Methyl-1-Phenyl-2-Pyrazolin-5-one), A Novel Free Radical Scavenger, for Treatment of Cardiovascular Diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Edaravone, a novel radical scavenger, inhibits oxidative modification of low-density lipoprotein (LDL) and reverses oxidized LDL-mediated reduction in the expression of endothelial nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Edaravone neuroprotection effected by suppressing the gene expression of the Fas signal pathway following transient focal ischemia in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Edaravone in acute ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Comparison of Tenecteplase with Alteplase on clinical rating scores following small clot embolic strokes in rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

The lipophilic multifunctional antioxidant edaravone (radicut) improves behavior following embolic strokes in rabbits: a combination therapy study with tissue plasminogen activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Efficacy of edaravone in cardioembolic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Efficacy of edaravone, a free radical scavenger, for the treatment of acute lacunar infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Efficacy of the free radical scavenger, edaravone, for motor palsy of acute lacunar infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Edaravone (radical scavenger) versus sodium ozagrel (antiplatelet agent) in acute noncardioembolic ischemic stroke (EDO trial).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Does functional outcome in acute ischaemic stroke patients correlate with the amount of free-radical scavenger treatment? A retrospective study of edaravone therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Determinants for the prognosis of acute renal disorders that developed during or after treatment with edaravone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

Administration of free radical scavenger edaravone associated with higher frequency of hemorrhagic transformation in patients with cardiogenic embolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14656566.2010.493558

The neuroprotective effect of a free radical scavenger and mild hypothermia following transient focal ischemia in rats

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Oxidative stress in brain ischemia.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891515

Delayed Tissue-Plasminogen Activator Therapy in a Rabbit Model of Thromboembolic Stroke

29 October 2018

1 reference

12 December 2020

Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage

1 reference

12 December 2020

NXY-059 for the treatment of acute ischemic stroke

1 reference

12 December 2020

Edaravone for the treatment of acute cerebral infarction: role of endothelium-derived nitric oxide and oxidative stress

1 reference

12 December 2020

The rtPA (alteplase) 0- to 6-hour acute stroke trial, part A (A0276g) : results of a double-blind, placebo-controlled, multicenter study. Thromblytic therapy in acute ischemic stroke study investigators

1 reference

12 December 2020

Ischemic stroke subtypes : a population-based study of functional outcome, survival, and recurrence

1 reference

12 December 2020

1 reference

12 December 2020

MCI-186: further histochemical and biochemical evidence of neuroprotection

1 reference

12 December 2020

10.1517/14656566.2010.493558

Identifiers

DOI

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30 July 2017

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30 July 2017

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