The novel antioxidant edaravone: from bench to bedside (Q46591722)

23 December 2017

title

The novel antioxidant edaravone: from bench to bedside (English)

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23 December 2017

2 references

ChEBI release 2020-05-28

Toshiaki Watanabe

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23 December 2017

Munenori Tahara

series ordinal

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23 December 2017

Satoru Todo

series ordinal

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23 December 2017

publication date

1 January 2008

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23 December 2017

Cardiovascular Therapeutics

published in

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23 December 2017

volume

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23 December 2017

issue

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23 December 2017

page(s)

101-114

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23 December 2017

Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger

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A new free radical scavenger, edaravone, ameliorates oxidative liver damage due to ischemia-reperfusion in vitro and in vivo

21 January 2018

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In vivo radioprotection of mice by 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone; Radicut), a clinical drug

21 January 2018

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21 January 2018

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Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging

21 January 2018

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The radical scavenger edaravone prevents oxidative neurotoxicity induced by peroxynitrite and activated microglia.

21 January 2018

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Inflammatory mediators and stroke: new opportunities for novel therapeutics

21 January 2018

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Dehydroascorbic acid normalizes several markers of oxidative stress and inflammation in acute hyperglycemic focal cerebral ischemia in the rat.

21 January 2018

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21 January 2018

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Pathophysiology of cerebral ischemia and brain trauma: similarities and differences

21 January 2018

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Inflammatory mechanisms after ischemia and stroke

21 January 2018

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Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney.

21 January 2018

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Free radicals in cerebral ischemia

21 January 2018

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Nitrones as therapeutics in age-related diseases

21 January 2018

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Transient cerebral ischemia and brain prostaglandins

21 January 2018

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Efficacy of edaravone, a free radical scavenger, on left ventricular function and structure in diabetes mellitus

21 January 2018

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Protective effect of edaravone against streptomycin-induced vestibulotoxicity in the guinea pig.

21 January 2018

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Effect of edaravone on streptomycin-induced vestibulotoxicity in the Guinea pig.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Cerebral ischemia and inflammation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Edaravone inhibits acute renal injury and cyst formation in cisplatin-treated rat kidney

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Inhibition of oxygen toxicity by targeting superoxide dismutase to endothelial cell surface

21 January 2018

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Antioxidant effect of MCI-186, a new Free-Radical scavenger, on ischemia-reperfusion injury in a rat hindlimb amputation model

21 January 2018

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Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat.

21 January 2018

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Effect of edaravone, a novel free radical scavenger, on endothelium-dependent vasodilation in smokers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Presidental address. Neuropathological aspects of brain edema

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

The radical scavenger edaravone enhances the anti-tumor effects of CPT-11 in murine colon cancer by increasing apoptosis via inhibition of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical-scavenging activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Blood-brain barrier disruption and exacerbation of ischemic brain edema after restoration of blood flow in experimental focal cerebral ischemia

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

NXY-059 for acute ischemic stroke

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Free radical scavenger protects against inner hair cell loss after cochlear ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Comparison of the radical trapping ability of PBN, S-PPBN and NXY-059.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part I: enhanced astrocytic synthesis of s-100beta in the periinfarct area precedes delayed infarct expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Selecting patients for early stroke treatment with penumbra images

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Effects of edaravone on human neutrophil function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

'Spectacular shrinking deficit': rapid recovery from a major hemispheric syndrome by migration of an embolus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Inhibitory effect of MCI-186, a free radical scavenger, on cerebral ischemia following rat middle cerebral artery occlusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

A free radical scavenger, edaravone (MCI-186), diminishes intestinal neutrophil lipid peroxidation and bacterial translocation in a rat hemorrhagic shock model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Simultaneous measurement of salicylate hydroxylation and glutamate release in the penumbral cortex following transient middle cerebral artery occlusion in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Synthesis of compounds with properties of leukotrienes C4 and D4 in gerbil brains after ischemia and reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

The control of vascular endothelial cell injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

A Free Radical Scavenger, Edaravone, Attenuates Steatosis and Cell Death via Reducing Inflammatory Cytokine Production in Rat Acute Liver Injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

MCI-186 (edaravone), a novel free radical scavenger, protects against acute autoimmune myocarditis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Beneficial effect of MCI-186 on hepatic warm ischemia-reperfusion in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

The hydroxyl radical scavenger MCI-186 protects the liver from experimental cold ischaemia-reperfusion injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Effect of MCI-186 on brain edema in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Inhibitory effect of free radical scavenger, MCI-186, in the increase of hydroxyl radical induced by iminodipropionitrile in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Pretreatment with the free radical scavenger edaravone prevents cerebral hyperperfusion after carotid endarterectomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Effects of the free radical scavenger, edaravone, on the development of postoperative cognitive impairment in patients undergoing carotid endarterectomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Neuroprotection and enhanced recovery with edaravone after acute spinal cord injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Edaravone protects against ischemia/reperfusion-induced oxidative damage to mitochondria in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Increased Formation of Reactive Oxygen Species after Permanent and Reversible Middle Cerebral Artery Occlusion in the Rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

MCI-186 (edaravone), a free radical scavenger, attenuates ischemia-reperfusion injury and activation of phospholipase A(2) in an isolated rat lung model after 18 h of cold preservation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

A novel free radical scavenger, edarabone, protects against cisplatin-induced acute renal damage in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Protection by a radical scavenger edaravone against cisplatin-induced nephrotoxicity in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

MCI-186 (edaravone), a free radical scavenger, attenuates hepatic warm ischemia-reperfusion injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Experimental study on the protective effects of edaravone against ischemic spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Clinical usefulness of edaravone for acute liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

A radical scavenger, edaravone, protects canine kidneys from ischemia-reperfusion injury after 72 hours of cold preservation and autotransplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

MCI-186 prevents spinal cord damage and affects enzyme levels of nitric oxide synthase and Cu/Zn superoxide dismutase after transient ischemia in rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

MCI-186 reduces oxidative cellular damage and increases DNA repair function in the rabbit spinal cord after transient ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

The clinical free radical scavenger, edaravone, protects cochlear hair cells from acoustic trauma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Protective effect of edaravone against the ototoxicity of Pseudomonas aeruginosa exotoxin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Protection from cerebral ischemia by a new imidazole derivative (Y-9179) and pentobarbital. A comparative study in chronic middle cerebral artery occlusion in cats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Post-exposure administration of edaravone attenuates noise-induced hearing loss.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Free radical scavenger (edaravone) prevents endotoxin-induced liver injury after partial hepatectomy in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

The antioxidant edaravone attenuates pressure overload-induced left ventricular hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Effects of edaravone on reperfusion injury in patients with acute myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Inhibition of brain damage by edaravone, a free radical scavenger, can be monitored by plasma biomarkers that detect oxidative and astrocyte damage in patients with acute cerebral infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Interobserver agreement for the assessment of handicap in stroke patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Structure-activity relationship of 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Research and development of the free radical scavenger edaravone as a neuroprotectant

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Myocardial protection of MCI-186 in rabbit ischemia-reperfusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Edaravone prevented deteriorated cardiac function after myocardial ischemia-reperfusion via inhibiting lipid peroxidation in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Application of in vivo ESR spectroscopy to measurement of cerebrovascular ROS generation in stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Protective effect of edaravone against hypoxia-reoxygenation injury in rabbit cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Correction of defective interdomain interaction within ryanodine receptor by antioxidant is a new therapeutic strategy against heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Edaravone, a novel radical scavenger, inhibits oxidative modification of low-density lipoprotein (LDL) and reverses oxidized LDL-mediated reduction in the expression of endothelial nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Extension of ischemic therapeutic time window by a free radical scavenger, Edaravone, reperfused with tPA in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Normalization by edaravone, a free radical scavenger, of irradiation-reduced endothelial nitric oxide synthase expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Post-ischemic inflammation: molecular mechanisms and therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

Role of prostaglandin endoperoxide PGG2 in inflammatory processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3466.2008.00041.X

10.1111/J.1527-3466.2008.00041.X

21 January 2018

Identifiers

DOI

1 reference

23 December 2017

1 reference

23 December 2017