Lestaurtinib inhibition of the Jak/STAT signaling pathway in hodgkin lymphoma inhibits proliferation and induces apoptosis (Q33886243)

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30 January 2020

title

Lestaurtinib inhibition of the Jak/STAT signaling pathway in hodgkin lymphoma inhibits proliferation and induces apoptosis (English)

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Tania Diaz

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Gerardo Ferrer

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Bernat Gel

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Anna Gaya

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Beatriz Bellosillo

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Mar Garcia-Garcia

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Sergi Serrano

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Antonio Martínez

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Mariano Monzo

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language of work or name

English

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publication date

20 April 2011

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volume

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issue

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page(s)

e18856

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Creative Commons Attribution 4.0 International

30 January 2020

start time

20 April 2011

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April 2022 Public Data File from Crossref

copyrighted

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cites work

Phase I study of a novel oral Janus kinase 2 inhibitor, SB1518, in patients with relapsed lymphoma: evidence of clinical and biologic activity in multiple lymphoma subtypes

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Lestaurtinib, a multitargeted tyrosine kinase inhibitor: from bench to bedside

5 July 2018

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Regulation of JAK2 by miR-135a: prognostic impact in classic Hodgkin lymphoma.

5 July 2018

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The biology of Hodgkin's lymphoma

5 July 2018

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Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2.

5 July 2018

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Treatment of Hodgkin lymphoma: the past, present, and future.

5 July 2018

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Risk, cure and complications in advanced hodgkin disease

5 July 2018

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Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders

5 July 2018

1 reference

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JAK2 inhibitor therapy in myeloproliferative disorders: rationale, preclinical studies and ongoing clinical trials

5 July 2018

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Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders

5 July 2018

1 reference

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Novel small-molecule therapy of Hodgkin lymphoma

5 July 2018

1 reference

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Identification and purification of classical Hodgkin cells from lymph nodes by flow cytometry and flow cytometric cell sorting

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080386

Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080386

Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2.

5 July 2018

1 reference

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Bcl-2-independent Bcr-Abl-mediated resistance to apoptosis: protection is correlated with up regulation of Bcl-xL.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080386

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3080386

Chemotherapy of advanced Hodgkin's disease with MOPP, ABVD, or MOPP alternating with ABVD

5 July 2018

1 reference

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STAT3 is constitutively activated in Hodgkin cell lines

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018856

Flow cytometry can diagnose classical hodgkin lymphoma in lymph nodes with high sensitivity and specificity

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018856

Recurrent numerical aberrations of JAK2 and deregulation of the JAK2-STAT cascade in lymphomas

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018856

Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cells

21 January 2018

1 reference

12 December 2020

Antiapoptotic marker Bcl-X(L), expression on Reed-Sternberg cells of Hodgkin's disease using a novel monoclonal marker, YTH-2H12

1 reference

12 December 2020

Absence of the JAK2 V617F activating mutation in classical Hodgkin lymphoma and primary mediastinal B-cell lymphoma

1 reference

12 December 2020

Expression of bcl2 family proteins and active caspase 3 in classical Hodgkin's lymphomas

1 reference

12 December 2020

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0018856

Identifiers

DOI

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30 January 2020

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1 reference

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30 January 2020

PubMed publication ID

21533094

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