Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2. (Q39942521)

15 September 2017

title

Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2. (English)

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15 September 2017

Joseph M Gozgit

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15 September 2017

Geraldine Bebernitz

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15 September 2017

Pankaj Patil

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15 September 2017

Minwei Ye

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15 September 2017

Julie Parmentier

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15 September 2017

Jiaquan Wu

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15 September 2017

Nancy Su

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15 September 2017

Tao Wang

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15 September 2017

Stephanos Ioannidis

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15 September 2017

Audrey Davies

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15 September 2017

Dennis Huszar

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15 September 2017

Michael Zinda

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15 September 2017

language of work or name

English

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publication date

4 September 2008

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Journal of Biological Chemistry

15 September 2017

published in

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15 September 2017

volume

283

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15 September 2017

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15 September 2017

page(s)

32334-32343

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Janus kinases: components of multiple signaling pathways

15 September 2017

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Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines

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Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL

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Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders

21 January 2018

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TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations

21 January 2018

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Establishment and characterization of a new human megakaryoblastic cell line (SET-2) that spontaneously matures to megakaryocytes and produces platelet-like particles

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JAK2 V617F: implications for thrombosis in myeloproliferative diseases

21 January 2018

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Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity

21 January 2018

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JAK2V617F-negative ET patients do not display constitutively active JAK/STAT signaling

21 January 2018

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Gene expression profiling of normal and malignant CD34-derived megakaryocytic cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M803813200

1 reference

15 September 2017

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