Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia (Q33859252)

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English	Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia	scientific article

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scholarly article

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Europe PubMed Central

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29 July 2017

Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia (English)

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29 July 2017

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frontotemporal dementia

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Daniel Geschwind

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Daniel H Geschwind

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29 July 2017

Bruce L. Miller

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Bruce L Miller

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29 July 2017

Robert V Farese

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Robert V Farese

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29 July 2017

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Basar Cenik

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29 July 2017

Chantelle F Sephton

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29 July 2017

Colleen M Dewey

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29 July 2017

Xunde Xian

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29 July 2017

Shuguang Wei

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29 July 2017

Kimberley Yu

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29 July 2017

Wenze Niu

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29 July 2017

Giovanni Coppola

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29 July 2017

Sarah E Coughlin

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29 July 2017

Suzee E Lee

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29 July 2017

Daniel R Dries

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29 July 2017

Sandra Almeida

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29 July 2017

Fen-Biao Gao

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29 July 2017

Bruce A Posner

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29 July 2017

Gang Yu

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Joachim Herz

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29 July 2017

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publication date

23 March 2011

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29 July 2017

Journal of Biological Chemistry

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29 July 2017

286

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29 July 2017

18

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29 July 2017

16101-16108

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29 July 2017

The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091219

5 July 2018

Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.

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5 July 2018

Frontotemporal dementia and primary progressive aphasia: an update

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Discovery of drug mode of action and drug repositioning from transcriptional responses

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Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A

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miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease

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MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia

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Pleiotropic mechanisms facilitated by resveratrol and its metabolites.

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Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia

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Anti-inflammatory activities of resveratrol in the brain: role of resveratrol in microglial activation

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SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

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5 July 2018

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

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5 July 2018

Resveratrol is neuroprotective because it is not a direct activator of Sirt1-A hypothesis

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5 July 2018

Pharmacology of epigenetics in brain disorders

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5 July 2018

Histone deacetylase inhibitors in cancer therapy

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5 July 2018

Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha

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5 July 2018

Lysine acetylation targets protein complexes and co-regulates major cellular functions

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5 July 2018

HDAC2 negatively regulates memory formation and synaptic plasticity.

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5 July 2018

Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members

1 reference

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5 July 2018

Therapeutic potential of resveratrol in Alzheimer's disease

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5 July 2018

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

1 reference

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5 July 2018

Mutations in progranulin (GRN) within the spectrum of clinical and pathological phenotypes of frontotemporal dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091219

5 July 2018

Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3091219

5 July 2018

FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma

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5 July 2018

Progranulin: normal function and role in neurodegeneration

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5 July 2018

Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents.

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5 July 2018

Progranulin in frontotemporal lobar degeneration and neuroinflammation

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5 July 2018

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: effects on gene expression and growth of glioma cells in vitro and in vivo

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5 July 2018

Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration

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5 July 2018

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

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5 July 2018

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

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Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

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Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation

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Survival in frontotemporal dementia

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Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

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Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

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Structural and functional analysis of a promoter of the human granulin/epithelin gene

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Serum biomarker for progranulin-associated frontotemporal lobar degeneration

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10.1074/JBC.M110.193433

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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