CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development (Q33832059)

29 July 2017

title

CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development (English)

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29 July 2017

Arthur Weiss

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29 July 2017

Julie Zikherman

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29 July 2017

Craig Jenne

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29 July 2017

Susan Watson

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29 July 2017

Kristin Doan

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29 July 2017

William Raschke

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29 July 2017

Christopher C Goodnow

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29 July 2017

language of work or name

English

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publication date

1 March 2010

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29 July 2017

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29 July 2017

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29 July 2017

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29 July 2017

page(s)

342-354

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Reduced levels of protein tyrosine phosphatase CD45 protect mice from the lethal effects of Ebola virus infection

29 July 2017

cites work

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PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.

4 July 2018

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CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells

4 July 2018

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Reduced expression of CD45 protein-tyrosine phosphatase provides protection against anthrax pathogenesis

4 July 2018

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Changes in the role of the CD45 protein tyrosine phosphatase in regulating Lck tyrosine phosphorylation during thymic development

4 July 2018

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Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.

4 July 2018

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Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation

4 July 2018

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Either of the CD45RB and CD45RO isoforms are effective in restoring T cell, but not B cell, development and function in CD45-null mice

4 July 2018

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4 July 2018

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4 July 2018

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Negative regulation of immunoreceptor signaling

4 July 2018

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Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T cell antigen receptor signal transduction

4 July 2018

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Genome-wide ENU mutagenesis to reveal immune regulators

4 July 2018

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4 July 2018

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Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

4 July 2018

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Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation

4 July 2018

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Signal transduction by the TCR for antigen

4 July 2018

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Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice

4 July 2018

1 reference

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CD45 and Src-family kinases: and now for something completely different

4 July 2018

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Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte development

4 July 2018

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CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity

4 July 2018

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Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains

4 July 2018

1 reference

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Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-zeta, and ZAP-70.

4 July 2018

1 reference

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Lineage commitment in the thymus: only the most differentiated (TCRhibcl-2hi) subset of CD4+CD8+ thymocytes has selectively terminated CD4 or CD8 synthesis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

4 July 2018

1 reference

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Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation

4 July 2018

1 reference

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Constitutive activation of Src family kinases in mouse embryos that lack Csk.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

Constitutive Tyrosine Phosphorylation of the T-Cell Receptor (TCR) ζ Subunit: Regulation of TCR-Associated Protein Tyrosine Kinase Activity by TCR ζ

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

Comparison of p56lck and p59fyn protein expression in thymocyte subsets, peripheral T cells, NK cells, and lymphoid cell lines

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

Distinct differentiative stages of CD4+CD8+ thymocyte development defined by the lack of coreceptor binding in positive selection.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

CD4+ T cell hyper-responsiveness in CD45 transgenic mice is independent of isoform

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

The juxtamembrane wedge negatively regulates CD45 function in B cells.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

CD45 isoforms in T cell signalling and development

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

A CD45 minigene restores regulated isoform expression and immune function in CD45-deficient mice: therapeutic implications for human CD45-null severe combined immunodeficiency

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

The GTPase Rac-1 controls cell fate in the thymus by diverting thymocytes from positive to negative selection.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

Csk controls antigen receptor-mediated development and selection of T-lineage cells.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

CD69 expression during selection and maturation of CD4+8+ thymocytes.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865198

Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain

29 October 2018

1 reference

12 December 2020

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1 reference

12 December 2020

T cell development in mice expressing splice variants of the protein tyrosine phosphatase CD45

1 reference

12 December 2020

Alterations in the level of CD45 surface expression affect the outcome of thymic selection

1 reference

12 December 2020

The CD45 tyrosine phosphatase regulates CD3-induced signal transduction and T cell development in recombinase-deficient mice: restoration of pre-TCR function by active p56(lck)

1 reference

12 December 2020

The constitutive tyrosine phosphorylation of CD3zeta results from TCR-MHC interactions that are independent of thymic selection

1 reference

12 December 2020

10.1016/J.IMMUNI.2010.03.006

Identifiers

DOI

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29 July 2017

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29 July 2017

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