Spontaneous rDNA copy number variation modulates Sir2 levels and epigenetic gene silencing (Q33826931)

29 July 2017

title

Spontaneous rDNA copy number variation modulates Sir2 levels and epigenetic gene silencing (English)

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29 July 2017

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Karine Dubrana

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Benoît Kornmann

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David Shore

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Agnès H Michel

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29 July 2017

publication date

1 May 2005

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29 July 2017

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29 July 2017

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29 July 2017

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29 July 2017

page(s)

1199-1210

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MAR1-a Regulator of the HMa and HMalpha Loci in SACCHAROMYCES CEREVISIAE

29 July 2017

cites work

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Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity

4 July 2018

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Calorie restriction extends yeast life span by lowering the level of NADH.

4 July 2018

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The replication fork barrier site forms a unique structure with Fob1p and inhibits the replication fork

4 July 2018

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Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencing

4 July 2018

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Spreading of Sir3 protein in cells with severe histone H3 hypoacetylation

4 July 2018

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Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

4 July 2018

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In exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rate rather than by the number of active genes

4 July 2018

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RNA polymerase I propagates unidirectional spreading of rDNA silent chromatin

4 July 2018

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A novel mitochondrial protein, Tar1p, is encoded on the antisense strand of the nuclear 25S rDNA.

4 July 2018

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Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

4 July 2018

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A role for the Saccharomyces cerevisiae RENT complex protein Net1 in HMR silencing.

4 July 2018

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Separation of mother and daughter cells

4 July 2018

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Mutations in WSC genes for putative stress receptors result in sensitivity to multiple stress conditions and impairment of Rlm1-dependent gene expression in Saccharomyces cerevisiae

4 July 2018

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Yeast RNA polymerase I enhancer is dispensable for transcription of the chromosomal rRNA gene and cell growth, and its apparent transcription enhancement from ectopic promoters requires Fob1 protein

4 July 2018

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Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association

4 July 2018

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Identification of DNA cis elements essential for expansion of ribosomal DNA repeats in Saccharomyces cerevisiae

4 July 2018

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The Saccharomyces cerevisiae RDN1 locus is sequestered from interchromosomal meiotic ectopic recombination in a SIR2-dependent manner.

4 July 2018

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Locus specificity determinants in the multifunctional yeast silencing protein Sir2

4 July 2018

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Analysis of Sir2p domains required for rDNA and telomeric silencing in Saccharomyces cerevisiae.

4 July 2018

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Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast.

4 July 2018

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Large-scale analysis of the yeast genome by transposon tagging and gene disruption

4 July 2018

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The economics of ribosome biosynthesis in yeast

4 July 2018

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity

4 July 2018

1 reference

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Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex

4 July 2018

1 reference

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Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Regulation of RNA polymerase I transcription in yeast and vertebrates

4 July 2018

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Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase I

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

The nuclear hormone receptor SEX-1 is an X-chromosome signal that determines nematode sex.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Functional characterization of the N terminus of Sir3p

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Extrachromosomal rDNA circles--a cause of aging in yeast

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Localization of Sir2p: the nucleolus as a compartment for silent information regulators

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Hyperactivation of the silencing proteins, Sir2p and Sir3p, causes chromosome loss

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

An unusual form of transcriptional silencing in yeast ribosomal DNA

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Green fluorescent protein as a marker for gene expression and subcellular localization in budding yeast

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Gene conversion plays the major role in controlling the stability of large tandem repeats in yeast

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Suppressors of defective silencing in yeast: effects on transcriptional repression at the HMR locus, cell growth and telomere structure.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Chromatin structures and transcription of rDNA in yeast Saccharomyces cerevisiae

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

A mobile group I intron from Physarum polycephalum can insert itself and induce point mutations in the nuclear ribosomal DNA of saccharomyces cerevisiae

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

A method for the generation of YAC transgenic mice by pronuclear microinjection

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Mutations in eukaryotic 18S ribosomal RNA affect translational fidelity and resistance to aminoglycoside antibiotics

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Disturbance of normal cell cycle progression enhances the establishment of transcriptional silencing in Saccharomyces cerevisiae

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Transcription in the yeast rRNA gene locus: distribution of the active gene copies and chromatin structure of their flanking regulatory sequences

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Characterization of two genes required for the position-effect control of yeast mating-type genes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Simple Mendelian Inheritance of the Repeating Yeast Ribosomal DNA Genes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

SIR2 regulates recombination between different rDNA repeats, but not recombination within individual rRNA genes in yeast

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Regulation of subtelomeric silencing during stress response.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Net1 stimulates RNA polymerase I transcription and regulates nucleolar structure independently of controlling mitotic exit.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Numerous potentially functional but non-genic conserved sequences on human chromosome 21

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1132006

Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae

29 October 2018

1 reference

12 December 2020

Unequal meiotic recombination within tandem arrays of yeast ribosomal DNA genes

1 reference

12 December 2020

Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap 1 protein

1 reference

12 December 2020

Differential gene expression studies to explore the molecular pathophysiology of Down syndrome

1 reference

12 December 2020

Identifiers

DOI

10.1101/GAD.340205

1 reference

29 July 2017

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29 July 2017

1 reference