Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis (Q33713961)

28 July 2017

title

Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis (English)

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28 July 2017

Olga S Kustikova

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28 July 2017

Bernhard Schiedlmeier

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28 July 2017

Martijn H Brugman

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28 July 2017

Maike Stahlhut

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28 July 2017

Stefan Bartels

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28 July 2017

Zhixiong Li

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28 July 2017

Christopher Baum

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28 July 2017

publication date

16 June 2009

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28 July 2017

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28 July 2017

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28 July 2017

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28 July 2017

page(s)

1537-1547

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Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

28 July 2017

cites work

1 reference

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21 June 2018

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Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells.

21 June 2018

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Steel factor coordinately regulates the molecular signature and biologic function of hematopoietic stem cells

21 June 2018

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DNA bar coding and pyrosequencing to analyze adverse events in therapeutic gene transfer

21 June 2018

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Physiological promoters reduce the genotoxic risk of integrating gene vectors

21 June 2018

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21 June 2018

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The hematopoietic stem cell and its niche: a comparative view

21 June 2018

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An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation

21 June 2018

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Open conformation chromatin and pluripotency

21 June 2018

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Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo

21 June 2018

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Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy

21 June 2018

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Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

21 June 2018

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Hot spots of retroviral integration in human CD34+ hematopoietic cells

21 June 2018

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Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression

21 June 2018

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Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways

21 June 2018

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Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect

21 June 2018

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Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy

21 June 2018

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Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

21 June 2018

1 reference

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Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

21 June 2018

1 reference

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Overcoming promoter competition in packaging cells improves production of self-inactivating retroviral vectors

21 June 2018

1 reference

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Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

21 June 2018

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Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences

21 June 2018

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Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

21 June 2018

1 reference

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Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque

21 June 2018

1 reference

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Retroviral DNA integration--mechanism and consequences

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835258

Role of telomerase in hematopoietic stem cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835258

Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835258

How do stem cells find their way home?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835258

Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835258

21 June 2018

1 reference

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RTCGD: retroviral tagged cancer gene database

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835258

SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling

21 June 2018

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Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery

21 June 2018

1 reference

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In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells

21 June 2018

1 reference

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Gene therapy for immunodeficiency due to adenosine deaminase deficiency.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835258

Retroviral insertion site analysis in dominant haematopoietic clones

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835258

Resistance of mature T cells to oncogene transformation

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835258

Comparison of HIV-derived lentiviral and MLV-based gammaretroviral vector integration sites in primate repopulating cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835258

Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835258

Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835258

MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835258

Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835258

Complementary and independent function for Hoxb4 and Bmi1 in HSC activity

30 October 2018

1 reference

12 December 2020

Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells

1 reference

12 December 2020

Murine leukemia induced by retroviral gene marking

1 reference

12 December 2020

In vivo self-renewal of c-Kit+ Sca-1+ Lin(low/-) hemopoietic stem cells

1 reference

12 December 2020

Globin Lentiviral Vector Insertions Can Perturb the Expression of Endogenous Genes in β-thalassemic Hematopoietic Cells

1 reference

12 December 2020

Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16

1 reference

12 December 2020

Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice

1 reference

12 December 2020

Identifiers

DOI

10.1038/MT.2009.134

1 reference

28 July 2017

1 reference

28 July 2017

1 reference