Targeted deletion of ERK2 in cardiomyocytes attenuates hypertrophic response but provokes pathological stress induced cardiac dysfunction. (Q33714000)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24631771%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

title

Targeted deletion of ERK2 in cardiomyocytes attenuates hypertrophic response but provokes pathological stress induced cardiac dysfunction (English)

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10 March 2020

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10 March 2020

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10 March 2020

1 reference

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10 March 2020

Susanne Ulm

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10 March 2020

Min Zi

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10 March 2020

Hoyee Tsui

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10 March 2020

Shogo Endo

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10 March 2020

Yasushi Satoh

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10 March 2020

Ruoxi Wang

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10 March 2020

Elizabeth J Cartwright

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10 March 2020

Xin Wang

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10 March 2020

publication date

12 March 2014

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Journal of Molecular and Cellular Cardiology

10 March 2020

published in

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10 March 2020

volume

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10 March 2020

page(s)

104-116

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Effect of connective tissue growth factor on protein kinase expression and activity in human corneal fibroblasts

10 March 2020

cites work

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Specifically targeting ERK1 or ERK2 kills melanoma cells

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Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart

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21 June 2018

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IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload.

21 June 2018

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21 June 2018

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Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth

21 June 2018

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Extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in cardiac hypertrophy

21 June 2018

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Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury

21 June 2018

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MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

21 June 2018

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Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome

21 June 2018

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Tumour cell survival signalling by the ERK1/2 pathway

21 June 2018

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DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility

21 June 2018

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21 June 2018

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Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo

21 June 2018

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Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome

21 June 2018

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Reduced phosphatase activity of SHP-2 in LEOPARD syndrome: consequences for PI3K binding on Gab1

21 June 2018

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PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects

21 June 2018

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PTPN11 mutations and genotype-phenotype correlations in Noonan and LEOPARD syndromes

21 June 2018

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The RAF proteins take centre stage

21 June 2018

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Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

21 June 2018

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Hypertrophic cardiomyopathy in childhood

21 June 2018

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Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

21 June 2018

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Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation

21 June 2018

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Essential role for ERK2 mitogen-activated protein kinase in placental development

21 June 2018

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Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK.

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Cardiac-specific deletion of mkk4 reveals its role in pathological hypertrophic remodeling but not in physiological cardiac growth.

21 June 2018

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A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy

30 October 2018

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Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload

30 October 2018

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MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo

30 October 2018

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The Transcription Factor C/EBPβ Serves as a Master Regulator of Physiologic Cardiac Hypertrophy

30 October 2018

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30 October 2018

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Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

7 January 2021

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Akt signaling and growth of the heart

7 January 2021

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MEF2 activates a genetic program promoting chamber dilation and contractile dysfunction in calcineurin-induced heart failure

7 January 2021

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7 January 2021

Identifiers

DOI

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10 March 2020

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mapped directly with Wikidata item

24 November 2022

based on heuristic

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10 March 2020

PubMed publication ID

24631771

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