Cdk5 activity in the brain - multiple paths of regulation (Q33687591)

28 July 2017

title

Cdk5 activity in the brain - multiple paths of regulation (English)

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28 July 2017

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Kavita Shah

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28 July 2017

Debomoy K Lahiri

series ordinal

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28 July 2017

language of work or name

English

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publication date

1 June 2014

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28 July 2017

published in

Journal of Cell Science

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28 July 2017

volume

127

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28 July 2017

issue

Pt 11

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28 July 2017

page(s)

2391-2400

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Lessons from a BACE1 inhibitor trial: off-site but not off base.

28 July 2017

cites work

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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An Isoform of the Neuronal Cyclin-dependent Kinase 5 (Cdk5) Activator

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A family of human cdc2-related protein kinases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Purification and characterization of a novel proline-directed protein kinase from bovine brain

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Phosphorylation of p35 and p39 by Cdk5 determines the subcellular location of the holokinase in a phosphorylation-site-specific manner.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer's disease

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Expression of cyclin-dependent kinase 5 mRNA and protein in the human brain following acute ischemic stroke

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Cdk5 regulates axonal transport and phosphorylation of neurofilaments in cultured neurons

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

The cyclin-dependent kinase 5 activator, p39, is expressed in stripes in the mouse cerebellum.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

A peptide derived from cyclin-dependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Myt1: a Wee1-type kinase that phosphorylates Cdc2 on residue Thr14.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

A brain-specific activator of cyclin-dependent kinase 5.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Neurobiology: p25 protein in neurodegeneration

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4038939

Fas engagement induces neurite growth through ERK activation and p35 upregulation

30 October 2018

1 reference

12 December 2020

Identification of nuclear import mechanisms for the neuronal Cdk5 activator

1 reference

12 December 2020

Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia

1 reference

12 December 2020

Cyclin-dependent Kinase 5 (Cdk5) Activation Domain of Neuronal Cdk5 Activator

1 reference

12 December 2020

Evaluation of cyclin D1 expression and its subcellular distribution in mouse tissues

1 reference

12 December 2020

Brain-derived neurotrophic factor stimulates the neural differentiation of human umbilical cord blood-derived mesenchymal stem cells and survival of differentiated cells through MAPK/ERK and PI3K/Akt-dependent signaling pathways

1 reference

12 December 2020

Neurodegeneration in an Aβ-induced model of Alzheimer’s disease: the role of Cdk5

1 reference

12 December 2020

Cyclin I-Cdk5 governs survival in post-mitotic cells

1 reference

12 December 2020

An Integrated Approach to Genome Studies

1 reference

12 December 2020

Identifiers

DOI

10.1242/JCS.147553

1 reference

28 July 2017

1 reference

28 July 2017

1 reference