Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules (Q48405566)

11 February 2018

title

Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules (English)

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11 February 2018

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Satoru Takahashi

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11 February 2018

Taro Saito

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11 February 2018

Shin-ichi Hisanaga

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11 February 2018

Harish C Pant

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11 February 2018

Ashok B Kulkarni

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11 February 2018

language of work or name

English

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publication date

20 January 2003

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11 February 2018

Journal of Biological Chemistry

published in

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11 February 2018

volume

278

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11 February 2018

issue

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11 February 2018

page(s)

10506-10515

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11 February 2018

Differential phosphorylation of some proteins of the neuronal cytoskeleton during brain development

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Microtubule organization and dynamics dependent on microtubule-associated proteins

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Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding

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The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development

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Distribution of the phosphorylated microtubule-associated protein tau in developing cortical neurons.

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Differential distribution of tau proteins in developing cat cerebellum

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Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

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Fetal-type phosphorylation of the tau in paired helical filaments

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Developmental changes in tau phosphorylation: fetal tau is transiently phosphorylated in a manner similar to paired helical filament-tau characteristic of Alzheimer's disease.

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The extent of phosphorylation of fetal tau is comparable to that of PHF-tau from Alzheimer paired helical filaments

21 January 2018

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Ca2+- and calmodulin-dependent phosphorylation of microtubule-associated protein 2 and tau factor, and inhibition of microtubule assembly

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Multisite phosphorylation of tau proteins from rat brain

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Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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Tau phosphorylation at serine 396 and serine 404 by human recombinant tau protein kinase II inhibits tau's ability to promote microtubule assembly

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21 January 2018

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p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

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An Isoform of the Neuronal Cyclin-dependent Kinase 5 (Cdk5) Activator

21 January 2018

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Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

21 January 2018

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A novel disruption of cortical development in p35(-/-) mice distinct from reeler

21 January 2018

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The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

21 January 2018

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Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

21 January 2018

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The expression of Cdk5, p35, p39, and Cdk5 kinase activity in developing, adult, and aged rat brains.

21 January 2018

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21 January 2018

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21 January 2018

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Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes

21 January 2018

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In situ localization of tau mRNA in developing rat brain

21 January 2018

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Changes in the expression of novel Cdk5 activator messenger RNA (p39nck5ai mRNA) during rat brain development

21 January 2018

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Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system

21 January 2018

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Synaptic localization of p39, a neuronal activator of cdk5

21 January 2018

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Role of Cyclins in Neuronal Differentiation of Immortalized Hippocampal Cells

21 January 2018

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Neurotoxicity induces cleavage of p35 to p25 by calpain

21 January 2018

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Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.

21 January 2018

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Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29

21 January 2018

1 reference

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Processing of cdk5 Activator p35 to Its Truncated Form (p25) by Calpain in Acutely Injured Neuronal Cells

21 January 2018

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Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25

21 January 2018

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p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M211964200

1 reference

11 February 2018

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11 February 2018