Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity (Q33654550)

24749861

28 July 2017

title

Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity (English)

1 reference

28 July 2017

Sujeewa Ranatunga

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31 May 2020

Chih-Hang Anthony Tang

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31 May 2020

Chang Won Kang

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31 May 2020

Bernhard J Kloppenburg

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31 May 2020

Chih-Chi Andrew Hu

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31 May 2020

language of work or name

English

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publication date

2 May 2014

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24749861

Journal of Medicinal Chemistry

28 July 2017

published in

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31 May 2020

volume

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31 May 2020

issue

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31 May 2020

page(s)

4289-4301

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Targeting the unfolded protein response in disease.

31 May 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

Selective inhibition of the unfolded protein response: targeting catalytic sites for Schiff base modification

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

The impact of the unfolded protein response on human disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

The unfolded protein response: from stress pathway to homeostatic regulation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

The resurgence of covalent drugs

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

Regulation of basal cellular physiology by the homeostatic unfolded protein response

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

Principles of cancer therapy: oncogene and non-oncogene addiction

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

Flavivirus Infection Activates the XBP1 Pathway of the Unfolded Protein Response To Cope with Endoplasmic Reticulum Stress

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

The unfolded protein response: a novel component of the hypoxic stress response in tumors.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032190

14 July 2018

Identifiers

DOI

10.1021/JM5002452

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24749861%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24749861%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

24749861

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24749861%20AND%20SRC:MED&resulttype=core&format=json