Selective inhibition of the unfolded protein response: targeting catalytic sites for Schiff base modification (Q38123951)

29 August 2017

title

Selective inhibition of the unfolded protein response: targeting catalytic sites for Schiff base modification (English)

1 reference

29 August 2017

1 reference

29 August 2017

Heather P Harding

0 references

Peter J Bond

0 references

Benedict C S Cross

1 reference

29 August 2017

Susana M Tomasio

1 reference

29 August 2017

publication date

1 October 2013

1 reference

29 August 2017

1 reference

29 August 2017

1 reference

29 August 2017

1 reference

29 August 2017

page(s)

2408-2416

1 reference

The impact of the unfolded protein response on human disease

29 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Delivering proteins for export from the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Endoplasmic reticulum stress sensing in the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

IRE1α activation protects mice against acetaminophen-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

RETRACTED: The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Molecular dynamics simulations and drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Biomolecular simulation: a computational microscope for molecular biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Multiscale molecular dynamics simulations of membrane proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

The simulation approach to lipid-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

The future of molecular dynamics simulations in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Binding of small-molecule ligands to proteins: "what you see" is not always "what you get".

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Dynamics of the antigen-binding grooves in CD1 proteins: reversible hydrophobic collapse in the lipid-free state.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Molecular mechanism of selective recruitment of Syk kinases by the membrane antigen-receptor complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Molecular recognition and ligand association

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Long time scale GPU dynamics reveal the mechanism of drug resistance of the dual mutant I223R/H275Y neuraminidase from H1N1-2009 influenza virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Best practices in free energy calculations for drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Good practices in free-energy calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Analysis of accessible surface of residues in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Structural basis of perturbed pKa values of catalytic groups in enzyme active sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

All-atom empirical potential for molecular modeling and dynamics studies of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Implementation of the CHARMM Force Field in GROMACS: Analysis of Protein Stability Effects from Correction Maps, Virtual Interaction Sites, and Water Models

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Structural and functional basis for RNA cleavage by Ire1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

RNA recognition and cleavage by a splicing endonuclease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Ribonuclease a: revealing structure-function relationships with semisynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Immune versus natural selection: antibody aldolases with enzymic rates but broader scope

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

The resurgence of covalent drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Large shifts in pK a values of lysine residues buried inside a protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

CHARMM: the biomolecular simulation program

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

VMD: visual molecular dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

Canonical sampling through velocity rescaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

In a staphylococcal nuclease mutant the side-chain of a lysine replacing valine 66 is fully buried in the hydrophobic core

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB70234K

21 January 2018

Identifiers

DOI

10.1039/C3MB70234K

1 reference

29 August 2017

1 reference