Epistasis and natural selection shape the mutational architecture of complex traits (Q33625608)

24828461

28 July 2017

title

Epistasis and natural selection shape the mutational architecture of complex traits (English)

1 reference

28 July 2017

1 reference

Reinhard Bürger

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24828461%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

language of work or name

English

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publication date

14 May 2014

1 reference

24828461

28 July 2017

published in

Nature Communications

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24828461%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24828461%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

page(s)

3709

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24828461%20AND%20SRC:MED&resulttype=core&format=json

Compensatory evolution and the origins of innovations

3 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

Epistasis dominates the genetic architecture of Drosophila quantitative traits

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

The mystery of missing heritability: Genetic interactions create phantom heritability

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

Robustness and evolvability

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

Common SNPs explain a large proportion of the heritability for human height

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

Mutational robustness can facilitate adaptation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

Common disorders are quantitative traits

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

Finding the missing heritability of complex diseases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

Genetic variation in the pleiotropic association between physical activity and body weight in mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

The genetics of quantitative traits: challenges and prospects

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

Genetic mapping in human disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

Data and theory point to mainly additive genetic variance for complex traits

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

21 June 2018

The road to modularity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

Genetic variation in pleiotropy: differential epistasis as a source of variation in the allometric relationship between long bone lengths and body weight.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

Robustness and evolvability: a paradox resolved

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

The Genetic Covariance between Characters Maintained by Pleiotropic Mutations

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

The population genetic theory of hidden variation and genetic robustness.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

Stability of the G-matrix in a population experiencing pleiotropic mutation, stabilizing selection, and genetic drift

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

The adaptive landscape as a conceptual bridge between micro- and macroevolution

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

MULTIFACTORIAL GENETICSUNDERSTANDING QUANTITATIVE GENETIC VARIATION

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

The genetic architecture of quantitative traits

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

Pleiotropic models of polygenic variation, stabilizing selection, and epistasis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environments?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4024485

Perspective: Complex Adaptations and the Evolution of Evolvability

21 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4709

Common disorders are quantitative traits

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4709

Why epistasis is important for selection and adaptation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4709

Correlational Selection for Color Pattern and Antipredator Behavior in the Garter Snake Thamnophis ordinoides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4709

Evolution and stability of the G-matrix on a landscape with a moving optimum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4709

Epistasis and balanced polymorphism influencing complex trait variation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4709

A POPULATION GENETIC THEORY OF CANALIZATION.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4709

Predictions of the dynamics of a polygenic character under directional selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4709

Evolution of genetic architecture under directional selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4709

Genetic architecture and postzygotic reproductive isolation: evolution of Bateson-Dobzhansky-Muller incompatibilities in a polygenic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4709

Will population bottlenecks and multilocus epistasis increase additive genetic variance?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4709

Phenotypic plasticity facilitates mutational variance, genetic variance, and evolvability along the major axis of environmental variation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4709

Genetic Covariance of Fitness Correlates: What Genetic Correlations are Made of and Why it Matters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4709

Modeling genetic architecture: a multilinear theory of gene interaction

21 January 2018

1 reference

12 December 2020

Epistasis in polygenic traits and the evolution of genetic architecture under stabilizing selection

1 reference

12 December 2020

Quantitative variability and multilocus polymorphism under epistatic selection

1 reference

12 December 2020

Pleiotropic effects on mandibular morphology II: differential epistasis and genetic variation in morphological integration

1 reference

12 December 2020

Effects of genetic drift on variance components under a general model of epistasis

1 reference

12 December 2020

The role of epistatic gene interactions in the response to selection and the evolution of evolvability

1 reference

12 December 2020

THE MUTATION MATRIX AND THE EVOLUTION OF EVOLVABILITY

1 reference

12 December 2020

Evolution of adaptive phenotypic variation patterns by direct selection for evolvability

1 reference

12 December 2020

DOES EVOLUTIONARY PLASTICITY EVOLVE?

1 reference

12 December 2020

PERSPECTIVE: COMPLEX ADAPTATIONS AND THE EVOLUTION OF EVOLVABILITY.

1 reference

12 December 2020

ADAPTIVE RADIATION ALONG GENETIC LINES OF LEAST RESISTANCE.

1 reference

12 December 2020

QUANTITATIVE GENETIC ANALYSIS OF MULTIVARIATE EVOLUTION, APPLIED TO BRAIN:BODY SIZE ALLOMETRY.

1 reference

12 December 2020

GENETIC COVARIANCE OF FITNESS CORRELATES: WHAT GENETIC CORRELATIONS ARE MADE OF AND WHY IT MATTERS.

1 reference

12 December 2020

CORRELATIONAL SELECTION FOR COLOR PATTERN AND ANTIPREDATOR BEHAVIOR IN THE GARTER SNAKE THAMNOPHIS ORDINOIDES

1 reference

12 December 2020

Rare genetic variation at Zea mays crtRB1 increases beta-carotene in maize grain

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4709

7 January 2021

inferred from DOI database lookup

EFFECTIVE DEME SIZES DURING LONG-TERM EVOLUTION ESTIMATED FROM RATES OF CHROMOSOMAL REARRANGEMENT

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4709

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCOMMS4709

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24828461%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

3 June 2020

ADS bibcode

2014NatCo...5.3709J

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0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24828461%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

24828461

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24828461%20AND%20SRC:MED&resulttype=core&format=json