Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems (Q22122008)

Dimensions Publication ID

Dimensions

1017234177

Data and theory point to mainly additive genetic variance for complex traits

25 September 2022

language of work or name

English

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publication date

November 2008

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published in

Nature Reviews Genetics

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volume

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issue

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page(s)

855-67

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cites work

1 reference

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The frailty of adaptive hypotheses for the origins of organismal complexity

19 March 2017

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Complex genetic interactions in a quantitative trait locus

19 March 2017

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Multiple locus linkage analysis of genomewide expression in yeast

19 March 2017

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Genetic architecture of complex traits in plants

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Mapping pathways and phenotypes by systematic gene overexpression

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Global mapping of the yeast genetic interaction network

19 March 2017

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Systematic genetic analysis with ordered arrays of yeast deletion mutants

19 March 2017

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Evolution and tinkering

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Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map

19 March 2017

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Darwinian evolution can follow only very few mutational paths to fitter proteins

7 April 2017

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Exploiting the proteome to improve the genome-wide genetic analysis of epistasis in common human diseases

12 September 2017

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12 September 2017

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From classical genetics to quantitative genetics to systems biology: modeling epistasis

12 September 2017

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Defining genetic interaction

12 September 2017

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Genetic dissection of developmental pathways

12 September 2017

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The road to modularity.

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The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q.

12 September 2017

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Integrating physical and genetic maps: from genomes to interaction networks

12 September 2017

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Adaptive variation in beach mice produced by two interacting pigmentation genes

12 September 2017

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Exploring genetic interactions and networks with yeast

12 September 2017

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The genetic architecture of shoot branching in Arabidopsis thaliana: a comparative assessment of candidate gene associations vs. quantitative trait locus mapping

12 September 2017

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Genetic complexity and quantitative trait loci mapping of yeast morphological traits

12 September 2017

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Detection of gene x gene interactions in genome-wide association studies of human population data

12 September 2017

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Genomewide analysis of epistatic effects for quantitative traits in barley

12 September 2017

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Empirical fitness landscapes reveal accessible evolutionary paths

12 September 2017

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Simultaneous Stability of D=0 and D not equal0 for Multiplicative Viabilities at Two Loci.

12 September 2017

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Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions

12 September 2017

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Direct demonstration of an adaptive constraint

12 September 2017

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Statistical epistasis is a generic feature of gene regulatory networks

12 September 2017

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Dynamic genetic interactions determine odor-guided behavior in Drosophila melanogaster

12 September 2017

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Functional epistasis on a common MHC haplotype associated with multiple sclerosis

12 September 2017

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Experimental approaches to identify genetic networks

12 September 2017

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Epistatic interactions: how strong in disease and evolution?

12 September 2017

1 reference

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Genetics, development and evolution of adaptive pigmentation in vertebrates

12 September 2017

1 reference

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Machine learning for detecting gene-gene interactions: a review

12 September 2017

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Evolution of hormone-receptor complexity by molecular exploitation

12 September 2017

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Genetic interactions between polymorphisms that affect gene expression in yeast

12 September 2017

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Perspective: Sign epistasis and genetic constraint on evolutionary trajectories

12 September 2017

1 reference

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Epistatic pleiotropy and the genetic architecture of covariation within early and late-developing skull trait complexes in mice

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2689140

Traversing the conceptual divide between biological and statistical epistasis: systems biology and a more modern synthesis

12 September 2017

1 reference

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Combining biological networks to predict genetic interactions

12 September 2017

1 reference

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Mapping complex disease loci in whole-genome association studies

12 September 2017

1 reference

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The Ubiquitous Nature of Epistasis in Determining Susceptibility to Common Human Diseases

12 September 2017

1 reference

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Perspective: Evolution and detection of genetic robustness

12 September 2017

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Cancer susceptibility in the mouse: genetics, biology and implications for human cancer

12 September 2017

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The color loci of mice--a genetic century

12 September 2017

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Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans

12 September 2017

1 reference

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Turning clustering loops: sex determination in Caenorhabditis elegans

12 September 2017

1 reference

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12 September 2017

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12 September 2017

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12 September 2017

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The language of gene interaction

12 September 2017

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12 September 2017

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12 September 2017

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Evidence for parallel processing of sensory information controlling dauer formation in Caenorhabditis elegans

12 September 2017

1 reference

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Epistasis and its contribution to genetic variance components.

12 September 2017

1 reference

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12 September 2017

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Ordering gene function: the interpretation of epistasis in regulatory hierarchies

12 September 2017

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Genetics of postmating reproductive isolation in animals

12 September 2017

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Population genetic perspectives on the evolution of recombination.

27 September 2017

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A unified model for functional and statistical epistasis and its application in quantitative trait Loci analysis.

27 September 2017

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Biochemical networks and epistasis shape the Arabidopsis thaliana metabolome

30 May 2018

1 reference

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Evolutionary plasticity of genetic interaction networks

29 November 2018

1 reference

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Prediction of phenotype and gene expression for combinations of mutations

29 November 2018

1 reference

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Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels.

29 November 2018

1 reference

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Renin–angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: Detection of high order gene–gene interaction

29 November 2018

1 reference

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Epistasis Between Type 2 Diabetes Susceptibility Loci on Chromosomes 1q21-25 and 10q23-26 in Northern Europeans

29 November 2018

1 reference

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Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways

29 November 2018

1 reference

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Epistasis and the release of genetic variation during long-term selection

29 November 2018

1 reference

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The synthetic genetic interaction spectrum of essential genes

29 November 2018

1 reference

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Genome-wide strategies for detecting multiple loci that influence complex diseases.

29 November 2018

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Modular epistasis in yeast metabolism.

29 November 2018

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Epistasis: too often neglected in complex trait studies?

29 November 2018

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Studying complex biological systems using multifactorial perturbation.

29 November 2018

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Sample size requirements for association studies of gene-gene interaction

29 November 2018

1 reference

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The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans

29 November 2018

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QTL-based evidence for the role of epistasis in evolution

29 November 2018

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Epistasis, complex traits, and mapping genes

31 March 2020

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Modeling genetic architecture: a multilinear theory of gene interaction

31 March 2020

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GENE EFFECTS ON A QUANTITATIVE TRAIT: TWO-LOCUS EPISTATIC EFFECTS MEASURED AT MICROSATELLITE MARKERS AND AT ESTIMATED QTL.

31 March 2020

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Genetics and metabolism in Neurospora

31 March 2020

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31 March 2020

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Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci

31 March 2020

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Both additivity and epistasis control the genetic variation for fruit quality traits in tomato

31 March 2020

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Multiple sclerosis: putting two and two together

31 March 2020

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PERSPECTIVE:EVOLUTION AND DETECTION OF GENETIC ROBUSTNESS

31 March 2020

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General two-locus selection models: Some objectives, results and interpretations

31 March 2020

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Multiple knockout analysis of genetic robustness in the yeast metabolic network

31 March 2020

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The Correlation between Relatives on the Supposition of Mendelian Inheritance

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRG2452

1 reference

Dimensions Publication ID

1017234177

0 references

Fatcat ID

release_zptt4a4lczdynefeh7dwhhzqfy

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/zptt4a4lczdynefeh7dwhhzqfy

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

1 reference

PubMed publication ID

18852697

1 reference