Ikaros silences T-bet expression and interferon-gamma production during T helper 2 differentiation (Q33593953)

28 July 2017

title

Ikaros silences T-bet expression and interferon-gamma production during T helper 2 differentiation (English)

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28 July 2017

Edward J Pearce

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28 July 2017

Rajan M Thomas

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28 July 2017

Chunxia Chen

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28 July 2017

Neelanjana Chunder

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28 July 2017

Lingzhi Ma

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28 July 2017

Justin Taylor

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28 July 2017

Andrew D Wells

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28 July 2017

language of work or name

English

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publication date

18 November 2009

1 reference

Journal of Biological Chemistry

28 July 2017

published in

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28 July 2017

volume

285

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28 July 2017

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28 July 2017

page(s)

2545-2553

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Cutting edge: Ikaros is a regulator of Th2 cell differentiation

28 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

Ikaros enforces the costimulatory requirement for IL2 gene expression and is required for anergy induction in CD4+ T lymphocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

Inhibition of IFN-gamma transcription by site-specific methylation during T helper cell development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

T helper cell differentiation: regulation by cis elements and epigenetics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

Regulation of Th2 differentiation and Il4 locus accessibility.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

A distinct region of the murine IFN-gamma promoter is hypomethylated from early T cell development through mature naive and Th1 cell differentiation, but is hypermethylated in Th2 cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

Th2 response polarization during infection with the helminth parasite Schistosoma mansoni

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

An epigenetic view of helper T cell differentiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

Haematopoietic cell-fate decisions, chromatin regulation and ikaros

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

Signaling and transcription in T helper development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

A novel transcription factor, T-bet, directs Th1 lineage commitment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

The Ikaros gene is required for the development of all lymphoid lineages

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2807311

Epigenetic remodeling of the IL-2 and IFN-gamma loci in memory CD8 T cells is influenced by CD4 T cells.

21 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.038794

Role of T-bet in commitment of TH1 cells before IL-12-dependent selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.038794

GATA-3 suppresses IFN-gamma promoter activity independently of binding to cis-regulatory elements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.038794

The Proximal Regulatory Element of the Interferon-γ Promoter Mediates Selective Expression in T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.038794

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

21 January 2018

1 reference

12 December 2020

A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma

1 reference

12 December 2020

Ikaros sets thresholds for T cell activation and regulates chromosome propagation

1 reference

12 December 2020

Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells

1 reference

12 December 2020

Blimp-1 attenuates Th1 differentiation by repression of ifng, tbx21, and bcl6 gene expression

1 reference

12 December 2020

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M109.038794

1 reference

28 July 2017

1 reference

28 July 2017

1 reference