Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells (Q35750923)

10 August 2017

title

Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells (English)

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10 August 2017

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10 August 2017

Irene Puga

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Sanmay Bandyopadhyay

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10 August 2017

Myrianne Duré

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10 August 2017

Monika Paroder

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10 August 2017

Noemí Soto-Nieves

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10 August 2017

language of work or name

English

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publication date

1 April 2007

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10 August 2017

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inferred from page(s)

published in

Blood

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10 August 2017

volume

109

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10 August 2017

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10 August 2017

page(s)

2878-2886

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T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha

10 August 2017

cites work

1 reference

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The dynamics of chromatin remodeling at promoters

12 July 2018

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NFAT proteins: key regulators of T-cell development and function

12 July 2018

1 reference

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Assembly of silent chromatin during thymocyte development

12 July 2018

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12 July 2018

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Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

12 July 2018

1 reference

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Transcriptional regulation by calcium, calcineurin, and NFAT

12 July 2018

1 reference

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The control of T cell activation vs. tolerance

12 July 2018

1 reference

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GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells

12 July 2018

1 reference

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Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice

12 July 2018

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12 July 2018

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Transcriptional mechanisms underlying lymphocyte tolerance.

12 July 2018

1 reference

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A molecular dissection of the repression circuitry of Ikaros

12 July 2018

1 reference

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Haematopoietic cell-fate decisions, chromatin regulation and ikaros

12 July 2018

1 reference

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Chromatin structure and gene regulation in the immune system

12 July 2018

1 reference

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Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator

12 July 2018

1 reference

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Partners in transcription: NFAT and AP-1.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

Evidence for repression of IL-2 gene activation in anergic T cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

Aiolos regulates B cell activation and maturation to effector state

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

Chromatin remodeling of the interleukin-2 gene: distinct alterations in the proximal versus distal enhancer regions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

Disruption of diacylglycerol metabolism impairs the induction of T cell anergy.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

CTLA-4 regulates induction of anergy in vivo

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852212

c-Rel is required for chromatin remodeling across the IL-2 gene promoter

23 October 2018

1 reference

12 December 2020

Murine CD4+CD25+ regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene

1 reference

12 December 2020

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness

1 reference

12 December 2020

Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody

1 reference

12 December 2020

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

1 reference

12 December 2020

The -180 site of the IL-2 promoter is the target of CREB/CREM binding in T cell anergy

1 reference

12 December 2020

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4+ T Cells

1 reference

12 December 2020

Blocked Ras activation in anergic CD4+ T cells

1 reference

12 December 2020

Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1

1 reference

12 December 2020

Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation

1 reference

12 December 2020

Ikaros sets thresholds for T cell activation and regulates chromosome propagation

1 reference

12 December 2020

Signals from CD28 induce stable epigenetic modification of the IL-2 promoter

1 reference

12 December 2020

10.1182/BLOOD-2006-07-037754

Identifiers

DOI

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10 August 2017

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10 August 2017

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