In vitro hepatic metabolism explains higher clearance of voriconazole in children versus adults: role of CYP2C19 and flavin-containing monooxygenase 3 (Q33574651)

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English	In vitro hepatic metabolism explains higher clearance of voriconazole in children versus adults: role of CYP2C19 and flavin-containing monooxygenase 3	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

In vitro hepatic metabolism explains higher clearance of voriconazole in children versus adults: role of CYP2C19 and flavin-containing monooxygenase 3 (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

1 reference

based on heuristic

inferred from title

Patrick F Augustijns

object named as

Patrick Augustijns

3

0 references

author name string

Souzan B Yanni

1

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Pieter P Annaert

2

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Europe PubMed Central

PubMed publication ID

28 July 2017

Joseph G Ibrahim

4

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Europe PubMed Central

PubMed publication ID

28 July 2017

Daniel K Benjamin

5

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Europe PubMed Central

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28 July 2017

Dhiren R Thakker

6

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Europe PubMed Central

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28 July 2017

publication date

1 January 2010

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Europe PubMed Central

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28 July 2017

Drug Metabolism and Disposition

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Europe PubMed Central

PubMed publication ID

28 July 2017

38

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Europe PubMed Central

PubMed publication ID

28 July 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

25-31

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Population pharmacokinetic analysis of voriconazole plasma concentration data from pediatric studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802422

14 July 2018

Hormonal regulation of hepatic drug-metabolizing enzyme activity during adolescence

1 reference

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14 July 2018

Using ontogeny information to build predictive models for drug elimination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802422

14 July 2018

Pharmacokinetics of mycophenolate mofetil and sirolimus in children.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802422

14 July 2018

Role of flavin-containing monooxygenase in oxidative metabolism of voriconazole by human liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802422

14 July 2018

Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802422

14 July 2018

Pharmacokinetic/pharmacodynamic profile of voriconazole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802422

14 July 2018

Clinical pharmacokinetics of voriconazole.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802422

14 July 2018

Ontogeny of drug elimination by the human kidney

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802422

14 July 2018

New antifungal agents under development in children and neonates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802422

14 July 2018

Prediction of drug disposition in infants and children by means of physiologically based pharmacokinetic (PBPK) modelling: theophylline and midazolam as model drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802422

14 July 2018

Pharmacokinetics of proton pump inhibitors in children

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802422

14 July 2018

Pharmacokinetics and safety of intravenous voriconazole in children after single- or multiple-dose administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802422

14 July 2018

Developmental pharmacology--drug disposition, action, and therapy in infants and children

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802422

14 July 2018

Pharmacokinetics and safety of voriconazole following intravenous- to oral-dose escalation regimens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802422

14 July 2018

The ontogeny of human drug-metabolizing enzymes: phase I oxidative enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802422

14 July 2018

Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802422

31 October 2018

A mechanistic approach for the scaling of clearance in children.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802422

31 October 2018

Prediction of cytochrome p450-mediated hepatic drug clearance in neonates, infants and children : how accurate are available scaling methods?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802422

31 October 2018

The disposition of voriconazole in mouse, rat, rabbit, guinea pig, dog, and human

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802422

31 October 2018

Identification of the Cytochrome P450 Enzymes Involved in theN-Oxidation of Voriconazole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2802422

31 October 2018

Prediction of human liver microsomal oxidations of 7-ethoxycoumarin and chlorzoxazone with kinetic parameters of recombinant cytochrome P-450 enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19841059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of Michaelis constants for cytochrome P450-mediated biotransformation reactions using a substrate depletion approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/19841059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/DMD.109.029769

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

ResearchGate publication ID

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